HIV-related bronchiectasis in children : an emerging spectre in high tuberculosis burden areas

Show simple item record Masekela, Refiloe Anderson, Ronald Moodley, Teshni Kitchin, Omolemo P. Risenga, Samuel Malamulele Becker, Piet J. Green, Robin J. 2012-02-13T13:05:54Z 2012-02-13T13:05:54Z 2012-01
dc.description.abstract BACKGROUND: Human immunodeficiency virus (HIV) infected children have an eleven-fold risk of acute lower respiratory tract infection. This places HIV-infected children at risk of airway destruction and bronchiectasis. OBJECTIVE: To study predisposing factors for the development of bronchiectasis in a developing world setting. METHODS: Children with HIV-related bronchiectasis aged 6–14 years were enrolled. Data were collected on demographics, induced sputum for tuberculosis, respiratory viruses (respiratory syncytial virus), influenza A and B, parainfluenza 1–3, adenovirus and cytomegalovirus), bacteriology and cytokines. Spirometry was performed. Blood samples were obtained for HIV staging, immunoglobulins, immunoCAP®-specific immunoglobulin E (IgE) for common foods and aeroallergens and cytokines. RESULTS: In all, 35 patients were enrolled in the study. Of 161 sputum samples, the predominant organisms cultured were Haemophilus influenzae and parainfluenzae (49%). The median forced expiratory volume in 1 second of all patients was 53%. Interleukin-8 was the predominant cytokine in sputum and serum. The median IgE level was 770 kU/l; however, this did not seem to be related to atopy; 36% were exposed to environmental tobacco smoke, with no correlation between and CD4 count. CONCLUSION: Children with HIV-related bronchiectasis are diagnosed after the age of 6 years and suffer significant morbidity. Immune stimulation mechanisms in these children are intact despite the level of immunosuppression. en_US
dc.description.sponsorship This study was funded by the Research Development Program Fund of the University of Pretoria awarded to RM. en_US
dc.description.uri en_US
dc.identifier.citation Masekela, R, Anderson, R, Moodley, T, Kitchin, OP, Risenga, SM, Becker, PJ & Green, RJ 2012, 'HIV-related bronchiectasis in children : an emerging spectre in high tuberculosis burden areas', International Journal of Tuberculosis and Lung Disease, vol. 16, no. 1, pp. 114-119. en_US
dc.identifier.issn 1027-3719 (print)
dc.identifier.issn 1815-7920 (online)
dc.identifier.other 10.5588/ijtld.11.0244
dc.language.iso en en_US
dc.publisher International Union Against Tuberculosis and Lung Disease en_US
dc.rights International Union Against Tuberculosis and Lung Disease. This article is embargoed by the publisher until June 2012. en_US
dc.subject Human immunodeficiency virus (HIV) en_US
dc.subject Tuberculosis en_US
dc.subject Bronchiectasis en_US
dc.subject Paediatrics en_US
dc.subject Cytokines en_US
dc.subject.lcsh Bronchitis in children en
dc.subject.lcsh HIV infections en
dc.subject.lcsh Respiratory infections en
dc.title HIV-related bronchiectasis in children : an emerging spectre in high tuberculosis burden areas en_US
dc.type Postprint Article en_US

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