Circulating cytokine profiles and their relationships with autoantibodies, acute phase reactants, and disease activity in patients with rheumatoid arthritis

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Meyer, Pieter Willem Adriaan
Hodkinson, Bridget
Ally, Mahmood Moosa Tar Mahomed
Musenge, Eustasius
Wadee, Ahmed A.
Fickl, Heidi
Tikly, Mohammed
Anderson, Ronald

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Hindawi Publishing Corporation

Abstract

Our objective was to analyse the relationship between circulating cytokines, autoantibodies, acute phase reactants, and disease activity in DMARDs-na¨ıve rheumatoid arthritis (RA) patients (n = 140). All cytokines were significantly higher in the RA cohort than in healthy controls. Moderate-to-strong positive intercorrelations were observed between Th1/Th2/macrophage/fibroblastderived cytokines. RF correlated significantly with IL-1β, IL-2, IL-4, IL-10, IL-12, G-CSF, GM-CSF, IFN-γ, and TNF (P < .0001), and aCCP and aMCV with IL-1β, IL-2, IL-4, and IL-10 (P < .0002), while IL-6 correlated best with the acute phase reactants, CRP, and SAA (P < .0001). In patients with a DAS28 score of ≥5.1, IFN-γ, IL-1β, IL-1Ra, TNF, GM-CSF, and VEGF were significantly correlated (P < .04–.001) with high disease activity (HDA). Circulating cytokines in RA reflect a multifaceted increase in immune reactivity encompassing Th1 and Th2 cells, monocytes/macrophages, and synovial fibroblasts, underscored by strong correlations between these cytokines, as well as their relationships with RF, aCCP, and aMCV, with some cytokines showing promise as biomarkers of HDA.

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Circulating cytokines, Autoantibodies, Acute phase reactants, Disease activity, Rheumatoid arthritis (RA) patients

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Citation

Meyer, PWA, Hodkinson, B, Ally, M, Musenge, E, Wadee, AA, Fickl, H, Tikly, M & Anderson, R 2010, 'Circulating cytokine profiles and their relationships with autoantibodies, acute phase reactants, and disease activity in patients with rheumatoid arthritis', Mediators of Inflammation, vol. 2010, Article ID. 158514, pp. 1-10.