Circulating cytokine profiles and their relationships with autoantibodies, acute phase reactants, and disease activity in patients with rheumatoid arthritis

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dc.contributor.author Meyer, P.W.A. (Pieter Willem Adriaan)
dc.contributor.author Hodkinson, Bridget
dc.contributor.author Ally, Mahmood Moosa Tar Mahomed
dc.contributor.author Musenge, Eustasius
dc.contributor.author Wadee, Ahmed A.
dc.contributor.author Fickl, Heidi
dc.contributor.author Tikly, Mohammed
dc.contributor.author Anderson, Ronald
dc.date.accessioned 2012-02-09T09:43:03Z
dc.date.available 2012-02-09T09:43:03Z
dc.date.issued 2010
dc.description.abstract Our objective was to analyse the relationship between circulating cytokines, autoantibodies, acute phase reactants, and disease activity in DMARDs-na¨ıve rheumatoid arthritis (RA) patients (n = 140). All cytokines were significantly higher in the RA cohort than in healthy controls. Moderate-to-strong positive intercorrelations were observed between Th1/Th2/macrophage/fibroblastderived cytokines. RF correlated significantly with IL-1β, IL-2, IL-4, IL-10, IL-12, G-CSF, GM-CSF, IFN-γ, and TNF (P < .0001), and aCCP and aMCV with IL-1β, IL-2, IL-4, and IL-10 (P < .0002), while IL-6 correlated best with the acute phase reactants, CRP, and SAA (P < .0001). In patients with a DAS28 score of ≥5.1, IFN-γ, IL-1β, IL-1Ra, TNF, GM-CSF, and VEGF were significantly correlated (P < .04–.001) with high disease activity (HDA). Circulating cytokines in RA reflect a multifaceted increase in immune reactivity encompassing Th1 and Th2 cells, monocytes/macrophages, and synovial fibroblasts, underscored by strong correlations between these cytokines, as well as their relationships with RF, aCCP, and aMCV, with some cytokines showing promise as biomarkers of HDA. en_US
dc.description.sponsorship The authors gratefully acknowledge financial support awarded by the South African Medical Research Council and the National Health Laboratory Service Research Trust of South Africa. en_US
dc.description.uri http://www.hindawi.com/journals/mi/ en_US
dc.identifier.citation Meyer, PWA, Hodkinson, B, Ally, M, Musenge, E, Wadee, AA, Fickl, H, Tikly, M & Anderson, R 2010, 'Circulating cytokine profiles and their relationships with autoantibodies, acute phase reactants, and disease activity in patients with rheumatoid arthritis', Mediators of Inflammation, vol. 2010, Article ID. 158514, pp. 1-10. en_US
dc.identifier.issn 0962-9351 (print)
dc.identifier.issn 1466-1861 (online)
dc.identifier.issn 10.1155/2010/158514
dc.identifier.uri http://hdl.handle.net/2263/18062
dc.language.iso en en_US
dc.publisher Hindawi Publishing Corporation en_US
dc.rights © 2010 Pieter W. A. Meyer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en_US
dc.subject Circulating cytokines en_US
dc.subject Autoantibodies en_US
dc.subject Acute phase reactants en_US
dc.subject Disease activity en_US
dc.subject Rheumatoid arthritis (RA) patients en_US
dc.subject.lcsh Cytokines en
dc.subject.lcsh Rheumatoid arthritis -- Research en
dc.title Circulating cytokine profiles and their relationships with autoantibodies, acute phase reactants, and disease activity in patients with rheumatoid arthritis en_US
dc.type Article en_US


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