Circulating cytokine profiles and their relationships with autoantibodies, acute phase reactants, and disease activity in patients with rheumatoid arthritis

dc.contributor.authorMeyer, Pieter Willem Adriaan
dc.contributor.authorHodkinson, Bridget
dc.contributor.authorAlly, Mahmood Moosa Tar Mahomed
dc.contributor.authorMusenge, Eustasius
dc.contributor.authorWadee, Ahmed A.
dc.contributor.authorFickl, Heidi
dc.contributor.authorTikly, Mohammed
dc.contributor.authorAnderson, Ronald
dc.contributor.emailranderso@postillion.up.ac.zaen_US
dc.date.accessioned2012-02-09T09:43:03Z
dc.date.available2012-02-09T09:43:03Z
dc.date.issued2010
dc.description.abstractOur objective was to analyse the relationship between circulating cytokines, autoantibodies, acute phase reactants, and disease activity in DMARDs-na¨ıve rheumatoid arthritis (RA) patients (n = 140). All cytokines were significantly higher in the RA cohort than in healthy controls. Moderate-to-strong positive intercorrelations were observed between Th1/Th2/macrophage/fibroblastderived cytokines. RF correlated significantly with IL-1β, IL-2, IL-4, IL-10, IL-12, G-CSF, GM-CSF, IFN-γ, and TNF (P < .0001), and aCCP and aMCV with IL-1β, IL-2, IL-4, and IL-10 (P < .0002), while IL-6 correlated best with the acute phase reactants, CRP, and SAA (P < .0001). In patients with a DAS28 score of ≥5.1, IFN-γ, IL-1β, IL-1Ra, TNF, GM-CSF, and VEGF were significantly correlated (P < .04–.001) with high disease activity (HDA). Circulating cytokines in RA reflect a multifaceted increase in immune reactivity encompassing Th1 and Th2 cells, monocytes/macrophages, and synovial fibroblasts, underscored by strong correlations between these cytokines, as well as their relationships with RF, aCCP, and aMCV, with some cytokines showing promise as biomarkers of HDA.en_US
dc.description.sponsorshipThe authors gratefully acknowledge financial support awarded by the South African Medical Research Council and the National Health Laboratory Service Research Trust of South Africa.en_US
dc.description.urihttp://www.hindawi.com/journals/mi/en_US
dc.identifier.citationMeyer, PWA, Hodkinson, B, Ally, M, Musenge, E, Wadee, AA, Fickl, H, Tikly, M & Anderson, R 2010, 'Circulating cytokine profiles and their relationships with autoantibodies, acute phase reactants, and disease activity in patients with rheumatoid arthritis', Mediators of Inflammation, vol. 2010, Article ID. 158514, pp. 1-10.en_US
dc.identifier.issn0962-9351 (print)
dc.identifier.issn1466-1861 (online)
dc.identifier.issn10.1155/2010/158514
dc.identifier.urihttp://hdl.handle.net/2263/18062
dc.language.isoenen_US
dc.publisherHindawi Publishing Corporationen_US
dc.rights© 2010 Pieter W. A. Meyer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.subjectCirculating cytokinesen_US
dc.subjectAutoantibodiesen_US
dc.subjectAcute phase reactantsen_US
dc.subjectDisease activityen_US
dc.subjectRheumatoid arthritis (RA) patientsen_US
dc.subject.lcshCytokinesen
dc.subject.lcshRheumatoid arthritis -- Researchen
dc.titleCirculating cytokine profiles and their relationships with autoantibodies, acute phase reactants, and disease activity in patients with rheumatoid arthritisen_US
dc.typeArticleen_US

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