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dc.contributor.author | Tonui, W.K.![]() |
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dc.contributor.author | Mpoke, S.S.![]() |
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dc.contributor.author | Orago, A.S.![]() |
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dc.contributor.author | Turco, S.J.![]() |
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dc.contributor.author | Mbati, P.A.![]() |
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dc.contributor.author | Mkoji, G.M.![]() |
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dc.contributor.editor | Boomker, Jacob Diederik Frederik | |
dc.date.accessioned | 2012-01-19T07:27:31Z | |
dc.date.available | 2012-01-19T07:27:31Z | |
dc.date.created | 2011 | |
dc.date.issued | 2003 | |
dc.description | The articles have been scanned with a HP Scanjet 8300; 600dpi, saved in TIFF format. Adobe Acrobat v.9 was used to OCR the text and also for the merging and conversion to the final presentation PDF-format. | en |
dc.description.abstract | The efficacy of Leishmania donovani-derived lipophosphoglycan (LPG) plus Mycobacterium bovis Bacille Calmette-Guerin (BCG) as a vaccine candidate against visceral leishmaniosis in susceptible BALB/c mouse and Syrian golden hamster (Mesocricetus auratus) models was investigated. Following a triple vaccination with a total dose of 150 µI BCG plus 60 µg or 30 µg of LPG for hamsters and BALB/c mice respectively, there were no noticeable side effects both locally and systemically; implying that the molecule was safe at this dosage level. Vaccinated animals demonstrated an activation of both the humoral as well as cell-mediated responses to LPG, which correlated with resistance against the disease. Protection by LPG plus BCG, was however, poor as the remaining immunized animals showed disease progression leading to severity of the disease as illustrated by emaciation, mass loss and heavy splenic parasitaemia in hamsters. These data nevertheless suggest that it may be rewarding to further evaluate the potential of LPG as a vaccine candidate in leishmaniosis using other adjuvants, which may enhance its immunogenicity. | en |
dc.description.librarian | mn2012 | en |
dc.description.sponsorship | Intemational Society for Infectious diseases (lSID). Intemational Atomic Agency (IAEA). Kenya Medical Research Institute. | en |
dc.identifier.citation | Tonui, WK, Mpoke, SS, Orago, AS, Turco, SJ, Mbati, PA & Mkoji, GM 2003, 'Leishmania donovani-derived lipophosphoglycan plus BCG induces a Th1 type immune response but does not protect Syrian golden hamsters (Mesocricetus auratus) and BALB/c mice against Leishmania donovani'. Onderstepoort Journal of Veterinary Research, vol. 70, no. 4, pp. 255-263. | en |
dc.identifier.issn | 0030-2465 | |
dc.identifier.uri | http://hdl.handle.net/2263/17837 | |
dc.language.iso | en | en |
dc.publisher | Pretoria : Agricultural Research Council, ARC-Onderstepoort Veterinary Institute and the University of Pretoria, Faculty of Veterinary Science | en |
dc.rights | © ARC-Onderstepoort and Faculty of Veterinary Science, University of Pretoria (original). © University of Pretoria. Dept of Library Services (digital). | en |
dc.subject | Veterinary medicine | en |
dc.subject | Bacille Calmette-Guerin | en |
dc.subject | BALB/c mice | en |
dc.subject | Leishmania donovani | en |
dc.subject | Lipophosphoglycan | en |
dc.subject | Syrian golden hamsters | en |
dc.subject.lcsh | Veterinary medicine -- South Africa | |
dc.subject.lcsh | Veterinary vaccines | en |
dc.title | Leishmania donovani-derived lipophosphoglycan plus BCG induces a Th1 type immune response but does not protect Syrian golden hamsters (Mesocricetus auratus) and BALB/c mice against Leishmania donovani | en |
dc.type | Article | en |
dc.type | Text | en_ZA |