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Browsing Research Articles (Microbiology and Plant Pathology) by Author "Ibrahim, Mohammed Auwal"

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The dipeptidyl peptidase IV inhibitory activity and multifunctional antidiabetic properties of SQSPA : structure – activity relationship evaluated with alanine scanning

Ibrahim, Mohammed Auwal; Serem, June Cheptoo; Bester, Megan Jean; Gaspar, Anabella Regina Marques (Elsevier, 2020-10)

Type 2 diabetes is a multifactorial disease and drugs with multifunctional properties are required. The peptide, SQSPA, was reported to be a potent and gastrointestinally stable α-glucosidase inhibitory peptide. In this ...
Multiple antidiabetic effects of three α-glucosidase inhibitory peptides, PFP, YPL and YPG : Dipeptidyl peptidase–IV inhibition, suppression of lipid accumulation in differentiated 3T3-L1 adipocytes and scavenging activity on methylglyoxal

Ibrahim, Mohammed Auwal; Serem, June Cheptoo; Bester, Megan Jean; Neitz, Albert Walter Herman; Gaspar, Anabella Regina Marques (Elsevier, 2019-02)

Antidiabetic agents with multiple targets have the greatest pharmaceutical potential. In this study, three α-glucosidase inhibitory peptides, PFP, YPL and YPG, were investigated for additional antidiabetic targets viz.; ...
New antidiabetic targets of α-glucosidase inhibitory peptides, SVPA, SEPA, STYV and STY: Inhibitory effects on dipeptidyl peptidase-IV and lipid accumulation in 3T3-L1 differentiated adipocytes with scavenging activities against methylglyoxal and reactive oxygen species

Ibrahim, Mohammed Auwal; Serem, June Cheptoo; Bester, Megan Jean; Neitz, Albert Walter Herman; Gaspar, Anabella Regina Marques (Springer, 2020-12)

Type 2 diabetes mellitus (T2DM) is a multifactorial disease that requires multiple therapeutic strategies for its management. Bioactive peptides with multiple anti-diabetic targets are attractive therapeutic molecules. The ...
Structure – function analysis of peptide analogs of SQSPA with respect to α-glucosidase and α-amylase inhibition

Ibrahim, Mohammed Auwal; Serem, June Cheptoo; Bester, Megan Jean; Neitz, Albert Walter Herman; Gaspar, Anabella Regina Marques (Bentham Science, 2019-07)

BACKGROUND : Peptide-based therapeutics offer a unique avenue for the development of novel agents for the treatment of diabetes mellitus including α-glucosidase inhibitors. The peptide, SQSPA, was reported to possess to α ...
Tuber storage proteins as potential precursors of bioactive peptides : an in silico analysis

Ibrahim, Mohammed Auwal; Bester, Megan Jean; Neitz, Albert Walter Herman; Gaspar, Anabella Regina Marques (Springer, 2019-06)

In silico analysis was used to evaluate storage proteins from plant tubers as potential precursors of bioactive peptides after simulated gastrointestinal digestion. Proteins derived from potato (patatins), sweet potato ...

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Browsing Research Articles (Microbiology and Plant Pathology) by Author "Ibrahim, Mohammed Auwal"

Browsing Research Articles (Microbiology and Plant Pathology) by Author "Ibrahim, Mohammed Auwal"

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