Browsing Research Articles (Microbiology and Plant Pathology) by Author "Klumperman, Bert"

Browsing Research Articles (Microbiology and Plant Pathology) by Author "Klumperman, Bert"

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  • Facile route to targeted, biodegradable polymeric prodrugs for the delivery of combination therapy for malaria 
    Fortuin, Lisa; Leshabane, Meta Kgaogelo; Pfukwa, Rueben; Coertzen, Dina; Birkholtz, Lyn-Marie; Klumperman, Bert (American Chemical Society, 2020-10)
    A facile synthetic methodology has been developed to prepare multifaceted polymeric prodrugs that are targeted, biodegradable, and nontoxic, and used for the delivery of combination therapy. This is the first instance of ...
  • Poly(N-vinylpyrrolidone) antimalaria conjugates of membrane-disruptive peptides 
    Jokonya, Simbarashe; Langlais, Marvin; Leshabane, Meta Kgaogelo; Reader, Paul W.; Vosloo, Johan A.; Pfukwa, Rueben; Coertzen, Dina; Birkholtz, Lyn-Marie; Rautenbach, Marina; Klumperman, Bert (American Chemical Society, 2020-11)
    The concepts of polymer–peptide conjugation and self-assembly were applied to antimicrobial peptides (AMPs) in the development of a targeted antimalaria drug delivery construct. This study describes the synthesis of α-acetal, ...