Browsing Research Articles (Biochemistry) by Author "Gay, Nicholas J."

Browsing Research Articles (Biochemistry) by Author "Gay, Nicholas J."

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  • The N-terminal loop of IRAK-4 death domain regulates ordered assembly of the Myddosome signalling scaffold 
    Dossang, Anthony C.G.; Motshwene, Precious G.; Yang, Yang; Symmons, Martyn F.; Bryant, Clare E.; Borman, Satty; George, Julie; Weber, Alexander N.R.; Gay, Nicholas J. (Nature Publishing Group, 2016-11-23)
    Activation of Toll-like receptors induces dimerization and the recruitment of the death domain (DD) adaptor protein MyD88 into an oligomeric post receptor complex termed the Myddosome. The Myddosome is a hub for inflammatory ...
  • Putative link between polo-like kinases (PLKs) and toll-like receptor (TLR) signaling in transformed and primary human immune cells 
    El Maadidi, Souhayla; Weber, Alexander N.R.; Motshwene, Precious G.; Schussler, Jan Moritz; Backes, Daniel; Dickhofer, Sabine; Wang, Hui; Liu, Xiao; Garcia, Magno Delmiro; Taumer, Christoph; Soufi, Boumediene; Wolz, Olaf-Oliver; Klimosch, Sascha N .; Franz-Wachtel, Mirita; Macek, Boris; Gay, Nicholas J. (Nature Publishing Group, 2019-09-11)
    Toll-like receptors (TLRs) are important sentinels of bacterial and viral infection and thus fulfil a critical sensory role in innate immunity. Polo-like kinases (PLKs), a five membered family of Ser/Thr protein kinases, ...