Browsing Research Articles (Biochemistry) by Author "Erlank, Erica"

Browsing Research Articles (Biochemistry) by Author "Erlank, Erica"

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  • Benzimidazole derivatives are potent against multiple life cycle stages of Plasmodium falciparum malaria parasites 
    Leshabane, Meta Kgaogelo; Dziwornu, Godwin Akpeko; Coertzen, Dina; Reader, Janette; Moyo, Phanankosi; Van der Watt, Mariette Elizabeth; Chisanga, Kelly; Nsanzubuhoro, Consolata; Ferger, Richard; Erlank, Erica; Venter, Nelius; Koekemoer, Lizette; Chibale, Kelly; Birkholtz, Lyn-Marie (American Chemical Society, 2021-03)
    The continued emergence of resistance to front-line antimalarial treatments is of great concern. Therefore, new compounds that potentially have a novel target in various developmental stages of Plasmodium parasites are ...
  • The ecdysone receptor regulates several key physiological factors in Anopheles funestus 
    Maharaj, Surina; Ekoka, Elodie; Erlank, Erica; Nardini, Luisa; Reader, Janette; Birkholtz, Lyn-Marie; Koekemoer, Lizette L. (BMC, 2022-03)
    BACKGROUND : Malaria is a devastating disease, transmitted by female Anopheles mosquitoes infected with Plasmodium parasites. Current insecticide-based strategies exist to control the spread of malaria by targeting vectors. ...
  • Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box 
    Reader, Janette; Van der Watt, Mariette Elizabeth; Taylor, Dale; Le Manach, Claire; Mittal, Nimisha; Ottilie, Sabine; Theron, Anjo; Moyo, Phanankosi; Erlank, Erica; Nardini, Luisa; Venter, Nelius; Lauterbach, Sonja; Bezuidenhout, Belinda; Horatscheck, Andre; Van Heerden, Ashleigh; Spillman, Natalie J.; Cowell, Anne N.; Connacher, Jessica I.; Opperman, Daniel; Orchard, Lindsey M.; Llinas, Manuel; Istvan, Eva S.; Goldberg, Daniel E.; Boyle, Grant A.; Calvo, David; Mancama, Dalu; Coetzer, Theresa L.; Winzeler, Elizabeth A.; Duffy, James; Koekemoer, Lizette L.; Basarab, Gregory; Chibale, Kelly; Birkholtz, Lyn-Marie (Nature Publishing Group, 2021-01)
    Chemical matter is needed to target the divergent biology associated with the different life cycle stages of Plasmodium. Here, we report the parallel de novo screening of the Medicines for Malaria Venture (MMV) Pandemic ...