Browsing Research Articles (Biochemistry) by Title

Browsing Research Articles (Biochemistry) by Title

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  • Evolution of the mating types and mating strategies in prominent genera in the Botryosphaeriaceae 
    Nagel, Jan Hendrik; Wingfield, Michael J.; Slippers, Bernard (Elsevier, 2018-05)
    Little is known regarding mating strategies in the Botryosphaeriaceae. To understand sexual reproduction in this fungal family, the mating type genes of Botryosphaeria dothidea and Macrophomina phaseolina, as well as several ...
  • Evolution of the tissue factor pathway inhibitor-like Kunitz domain-containing protein family in Rhipicephalus microplus 
    Louw, Elizabeth M.; Van der Merwe, Nicolaas Albertus (Albie); Neitz, Albert Walter Herman; Maritz-Olivier, Christine (Elsevier, 2013-01)
    One of the principle mechanisms utilised by ticks to obtain a blood meal is the subversion of the host’s haemostatic response. This is achieved through the secretion of saliva containing anti-haemostatic proteins into ...
  • The evolutionary conundrum of whole‐genome duplication 
    Carretero‐Paulet, Lorenzo; Van de Peer, Yves (Wiley, 2020-08)
    Whole‐genome duplication (WGD) is a dramatic, common event in plants. Because of the detrimental effects arising from doubling the entire chromosome set, such as minority cytotype exclusion, genomic instability, mitotic ...
  • Expected benefits of genomic selection for growth and wood quality traits in Eucalyptus grandis 
    Mphahlele, M.M. (Makobatjatji); Isik, Fikret; Mostert-O'Neill, Marja Mirjam; Reynolds, Sharon Melissa; Hodge, Gary R.; Myburg, Alexander Andrew (Springer, 2020-06)
    Genomic selection (GS) can substantially reduce breeding cycle times in forest trees compared to traditional breeding cycles. Practical implementation of GS in tree breeding requires an assessment of significant drivers ...
  • Exploring African medicinal plants for potential anti-diabetic compounds with the DIA-DB inverse virtual screening web server 
    Pereira, Andreia S.P.; Den Haan, Helena; Pena-Garcia, Jorge; Moreno, Marien M.; Perez-Sanchez, Horacio; Apostolides, Zeno (MDPI, 2019-05)
    Medicinal plants containing complex mixtures of several compounds with various potential beneficial biological effects are attractive treatment interventions for a complex multi-faceted disease like diabetes. In this ...
  • Exploring functional genomics for drug target and therapeutics discovery in Plasmodia 
    Birkholtz, Lyn-Marie; Van Brummelen, A.C. (Anna Catharina); Clark, Katherine; Niemand, Jandeli; Marechal, Eric; Llinas, M.; Louw, Abraham Izak (Elsevier, 2008-02)
    Functional genomics approaches are indispensable tools in the drug discovery arena and have recently attained increased attention in antibacterial drug discovery research. However, the application of functional genomics ...
  • Exploring inhibition of Pdx1, a component of the PLP synthase complex of the human malaria parasite Plasmodium falciparum 
    Reeksting, S.B. (Shaun Bernard); Muller, Ingrid B.; Burger, Pieter Buys; Burgos, Emmanuel S.; Salmon, Laurent; Louw, Abraham Izak; Birkholtz, Lyn-Marie; Wrenger, Carsten (Portland Press on behalf of the Biochemical Society, 2013)
    Malaria tropica is a devastating infectious disease caused by Plasmodium falciparum. This parasite synthesizes vitamin B6 de novo via the pyridoxal 5-phosphate (PLP) synthase enzymatic complex consisting of PfPdx1 and ...
  • Exploring the anti-proliferative activity of Pelargonium sidoides DC with in silico target identification and network pharmacology 
    Pereira, Andreia S.P.; Bester, Megan Jean; Apostolides, Zeno (Springer, 2017-11)
    Pelargonium sidoides DC (Geraniaceae) is a medicinal plant indigenous to Southern Africa that has been widely evaluated for its use in the treatment of upper respiratory tract infections. In recent studies, the anti-proliferative ...
  • Exploring the transmission-blocking activity of antiplasmodial 3,6-diarylated imidazopyridazines 
    Coertzen, Dina; Reader, Janette; Van der Watt, Mariette Elizabeth; Leshabane, Meta Kgaogelo; Langeveld, Henrico; Cheuka, Peter M.; Dziwornu, Godwin Akpeko; Chibale, Kelly; Birkholtz, Lyn-Marie (Taylor and Francis, 2021)
    The effectiveness of current antimalarial therapies that cure patients of the pathogenic asexual blood stages is rapidly declining due to the spread of antimalarial drug resistance. This requires the development of novel ...
  • Expression and production of soluble Mycobacterium tuberculosis H37Rv mycosin-3 
    Fang, Zhuo; Schubert, Wolf-Dieter; Van Pittius, Nicolaas Claudius Gey (Elsevier, 2016-02-06)
    Mycobacteria encode five type VII secretion system (T7SS) or ESX for nutrient acquisition and virulence. Mycosins are membrane-anchored components of ESX with serine protease activity but an unidentified substrate range. ...
  • Expression of several Phytophthora cinnamomi putative RxLRs provides evidence for virulence roles in avocado 
    Joubert, Melissa; Backer, Robert; Engelbrecht, Juanita; Van den Berg, Noelani (Public Library of Science, 2021-07)
    Phytophthora cinnamomi is a plant pathogenic oomycete that causes Phytophthora root rot of avocado (PRR). Currently, there is a limited understanding of the molecular interactions underlying this disease. Other Phytophthora ...
  • Extending the host range of Phytophthora multivora, a pathogen of woody plants in horticulture, nurseries, urban environments and natural ecosystems 
    Migliorini, Duccio; Khdiar, Mohammed Y.; Padron, Cristina Rodriguez; Vivas, Maria; Barber, Paul A.; Hardy, Giles E. St J.; Burgess, Treena I. (Elsevier, 2019-12)
    Phytophthora multivora is a recently described species with a global distribution associated with disease of many woody plant species. However, very few pathogenicity studies have been conducted to determine the host range ...
  • Extracellular vesicles in teasing apart complex plant-microbiota links : implications for microbiome-based biotechnology 
    Motaung, Thabiso Eric; Steenkamp, Emma Theodora (American Society for Microbiology, 2021-07)
    Extracellular vesicles (EVs) are subcellular carriers of bioactive compounds with a complex array of functional effects on target cells. In mammals, circulating bodily fluid microbiota EVs (mbEVs) deliver cargo from ...
  • Facial adiposity, attractiveness, and health : a review 
    De Jager, Stefan; Coetzee, Nicoleen; Coetzee, Vinet (BioMed Central, 2018-12-21)
    The relationship between facial cues and perceptions of health and attractiveness in others plays an influential role in our social interactions and mating behaviors. Several facial cues have historically been investigated ...
  • Facile route to targeted, biodegradable polymeric prodrugs for the delivery of combination therapy for malaria 
    Fortuin, Lisa; Leshabane, Meta Kgaogelo; Pfukwa, Rueben; Coertzen, Dina; Birkholtz, Lyn-Marie; Klumperman, Bert (American Chemical Society, 2020-10)
    A facile synthetic methodology has been developed to prepare multifaceted polymeric prodrugs that are targeted, biodegradable, and nontoxic, and used for the delivery of combination therapy. This is the first instance of ...
  • Fern genomes elucidate land plant evolution and cyanobacterial symbioses 
    Li, Fay-Wei; Brouwer, Paul; Carretero-Paulet, Lorenzo; Cheng, Shifeng; De Vries, Jan; Delaux, Pierre-Marc; Eily, Ariana; Koppers, Nils; Kuo, Li-Yaung; Li, Zheng; Simenc, Mathew; Small, Ian; Wafula, Eric; Angarita, Stephany; Barker, Michael S.; Brautigam, Andrea; DePamphilis, Claude; Gould, Sven; Hosmani, Prashant S.; Huang, Yao-Moan; Huettel, Bruno; Kato, Yoichiro; Liu, Xin; Maere, Steven; McDowell, Rose; Mueller, Lukas A.; Nierop, Klaas G.J.; Rensing, Stefan A.; Robison, Tanner; Rothfels, Carl J.; Sigel, Erin M.; Song, Yue; Timilsena, Prakash R.; Van de Peer, Yves; Wang, Hongli; Wilhelmsson, Per K.I.; Wolf, Paul G.; Xu, Xun; Der, Joshua P.; Schluepmann, Henriette; Wong, Gane K.-S.; Pryer, Kathleen M. (Nature Publishing Group, 2018-07-02)
    Ferns are the closest sister group to all seed plants, yet little is known about their genomes other than that they are generally colossal. Here, we report on the genomes of Azolla filiculoides and Salvinia cucullata ...
  • Few figs for frugivores : riparian fig trees in Zimbabwe may not be a dry season keystone resource 
    Compton, Stephen G.; Greeff, Jaco M. (Jacobus Maree) (Wiley, 2020-12)
    Most plants flower and fruit at times of year when probabilities of pollination and seedling establishment are high. Fig trees (Ficus spp.) are often considered as keystone resources for vertebrate frugivores, in part ...
  • Filamentous fungi and yeasts associated with mites phoretic on Ips typographus in Eastern Finland 
    Linnakoski, Riikka; Lasarov, Ilmeini; Veteli, Pyry; Tikkanen, Olli-Pekka; Viiri, Heli; Jyske, Tuula; Kasanen, Risto; Duong, Tuan A.; Wingfield, Michael J. (MDPI, 2021-06-04)
    The European spruce bark beetle (Ips typographus) has become a major forest pest in Finland in recent years. The beetle is a well-known vector of mainly ophiostomatoid fungi causing bluestain of timber and pathogens that ...
  • Finding stories in noise : Mitochondrial portraits from RAD data 
    Stobie, Connor Seamus; Cunningham, Michael J.; Oosthuizen, C.J. (Carel); Bloomer, Paulette (Wiley, 2019-01)
    many years; however, recent trends focus on genome‐wide analyses. One method proposed for calibrating inferences from noisy next‐generation data, such as RAD sequencing, is to compare these results with analyses of ...
  • First draft genome assembly of the Argane tree (Argania spinosa) [version 2; peer review: 2 approved] 
    Khayi, Slimane; Azza, Nour Elhouda; Gaboun, Fatima; Pirro, Stacy; Badad, Oussama; Lightfoot, David A.; Unver, Turgay; Chaouni, Bouchra; Merrouch, Redouane; Rahim, Bouchra; Essayeh, Soumaya; Ganoudi, Matika; Abdelwahd, Rabha; Diria, Ghizlane; Mdarhi, Meriem Alaoui; Labhilili, Mustapha; Iraqi, Driss; Claros, M Gonzalo; Mouhaddab, Jamila; Sedrati, Hayat; Memari, Majid; Hamamouch, Noureddine; De Dios Alche, Juan; Alche, Juan de Dios; Boukhatem, Noureddine; Mrabet, Rachid; Dahan, Rachid; Legssyer, Adelkhaleq; Khalfaoui, Mohamed; Badraoui, Mohamed; Van de Peer, Yves; Tatusova, Tatiana; El Mousadik, Abdelhamid; Mentag, Rachid; Ghazal, Hassan (F1000 Research, 2020)
    BACKGROUND : The Argane tree (Argania spinosa L. Skeels) is an endemic tree of mid-western Morocco that plays an important socioeconomic and ecologic role for a dense human population in an arid zone. Several studies ...