Petersen, Desiree C.; Jaratlerdsiri, Weerachai; Van Wyk, Abraham; Chan, Eva K.F.; Fernandez, Pedro; Lyons, Ruth J.; Mutambirw, Shingai B.A.; Van der Merwe, Andre; Bates, William; Bornman, Maria S. (Riana); Hayes, Vanessa M.(BioMed Central, 2019-06-04)
BACKGROUNDS : Genetic diversity is greatest within Africa, in particular the KhoeSan click-speaking peoples of
southern Africa. South African populations represent admixture fractions including differing degrees of ...
Heyer, Erin E.; Deveson, Ira W.; Wooi, Danson; Selinger, Christina I.; Lyons, Ruth J.; Hayes, Vanessa M.; O’Toole, Sandra A.; Ballinger, Mandy L.; Gill, Devinder; Thomas, David M.; Mercer, Tim R.; Blackburn, James(Nature Publishing Group, 2019-03-27)
Fusion genes are a major cause of cancer. Their rapid and accurate diagnosis can inform
clinical action, but current molecular diagnostic assays are restricted in resolution and
throughput. Here, we show that targeted ...
Feng, Ye; Jaratlerdsiri, Weerachai; Patrick, Sean Mark; Lyons, Ruth J.; Haynes, Anne‐Maree; Collins, Colin C.; Stricker, Phillip D.; Bornman, Maria S. (Riana); Hayes, Vanessa M.(Wiley, 2019-11)
BACKGROUND : Inflammation is a hallmark of prostate cancer (PCa), yet no pathogenic
agent has been identified. Men from Africa are at increased risk for both aggressive
prostate disease and infection. We hypothesize that ...
BACKGROUND : Prostate cancer (PCa) is the most common malignant neoplasm among men in many countries.
Since most precancerous and cancerous tissues show signs of inflammation, chronic bacterial prostatitis has been
LaBarre, Brenna A.; Goncearenco, Alexander; Petrykowska, Hanna M.; Jaratlerdsiri, Weerachai; Bornman, Maria S. (Riana); Hayes, Vanessa M.; Elnitski, Laura(BioMed Central, 2019-12-20)
BACKGROUND : Current array-based methods for the measurement of DNA methylation rely on the process of sodium
bisulfite conversion to differentiate between methylated and unmethylated cytosine bases in DNA. In the absence
Jaratlerdsiri, Weerachai; Chan, Eva K.F.; Petersen, Desiree C.; Yang, Claire; Croucher, Peter I.; Bornman, Maria S. (Riana); Sheth, Palak; Hayes, Vanessa M.(Impact Journals, 2017-03-01)
Complex genomic rearrangements are common molecular events driving prostate
carcinogenesis. Clinical significance, however, has yet to be fully elucidated. Detecting
the full range and subtypes of large structural variants ...
Chan, Eva K.F.; Cameron, Daniel L.; Petersen, Desiree C.; Lyons, Ruth J.; Baldi, Benedetta F.; Papenfuss, Anthony T.; Thomas, David M.; Hayes, Vanessa M.(Cold Spring Harbor Laboratory Press, 2018)
Genomic rearrangements are common in cancer, with demonstrated links to disease progression and treatment response.
These rearrangements can be complex, resulting in fusions of multiple chromosomal fragments and generation ...
Hayes, Vanessa M.; Bornman, Maria S. (Riana)(American Society of Clinical Oncology, 2017-03-21)
Prostate cancer (PCa) is the most common cancer
diagnosis in men from economically stable countries
and is a leading cause of cancer-related
death.1 However, the population with the highest
reported incidence and ...
We assembled genome-wide data from 16 prehistoric Africans. We show that the anciently divergent lineage that comprises the primary ancestry of the southern African San had a wider distribution in the past, contributing ...
Chan, Eva K.F.; Hardie, Rae-Anne; Petersen, Desiree C.; Beeson, Karen; Bornman, Maria S. (Riana); Smith, Andrew B.; Hayes, Vanessa M.(Public Library of Science, 2015-03-25)
The oldest extant human maternal lineages include mitochondrial haplogroups L0d and L0k found in the southern African click-speaking forager peoples broadly classified as Khoesan. Profiling these early mitochondrial lineages ...
McCrow, John P.; Petersen, Desiree C.; Louw, Melanie; Chan, Eva K. F.; Harmeyer, Katherine; Vecchiarelli, Stefano; Lyons, Ruth J.; Bornman, Maria S. (Riana); Hayes, Vanessa M.(Wiley, 2016-03)
BACKGROUND : Prostate cancer incidence and mortality rates are significantly increased in
African–American men, but limited studies have been performed within Sub–Saharan
African populations. As mitochondria control ...
Blackburn, James; Vecchiarelli, Stefano; Heyer, Erin E.; Patrick, Sean Mark; Lyons, Ruth J.; Jaratlerdsiri, Weerachai; Van Zyl, Smit; Bornman, Maria S. (Riana); Mercer, Tim R.; Hayes, Vanessa M.(Wiley, 2019-07)
BACKGROUND : The androgen‐regulated gene TMPRSS2 to the ETS transcription factor
gene ERG fusion is the most common genomic alteration acquired during prostate
tumorigenesis and biased toward men of European ancestry. ...