Browsing Research Articles (School of Health Systems and Public Health (SHSPH)) by UP Author "Hayes, Vanessa M."

Browsing Research Articles (School of Health Systems and Public Health (SHSPH)) by UP Author "Hayes, Vanessa M."

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  • African inclusion in prostate cancer genomic studies provides the first glimpses into addressing health disparities through tailored clinical care 
    Hayes, Vanessa M.; Gong, Tingting; Mutambirwa, Shingai B.A.; Jaratlerdsiri, Weerachai; Bornman, Maria S. (Riana) (Wiley, 2023-01)
    No abstract available.
  • African KhoeSan ancestry linked to high-risk prostate cancer 
    Petersen, Desiree C.; Jaratlerdsiri, Weerachai; Van Wyk, Abraham; Chan, Eva K.F.; Fernandez, Pedro; Lyons, Ruth J.; Mutambirw, Shingai B.A.; Van der Merwe, Andre; Bates, William; Bornman, Maria S. (Riana); Hayes, Vanessa M. (BioMed Central, 2019-06-04)
    BACKGROUNDS : Genetic diversity is greatest within Africa, in particular the KhoeSan click-speaking peoples of southern Africa. South African populations represent admixture fractions including differing degrees of ...
  • African-specific molecular taxonomy of prostate cancer 
    Jaratlerdsiri, Weerachai; Jiang, Jue; Gong, Tingting; Patrick, Sean Mark; Willet, Cali; Chew, Tracy; Lyons, Ruth J.; Haynes, Anne-Maree; Pasqualim, Gabriela; Louw, Melanie; Kench, James G.; Campbell, Raymond; Horvath, Lisa G.; Chan, Eva K.F.; Wedge, David C.; Sadsad, Rosemarie; Brum, Ilma Simoni; Mutambirwa, Shingai B.A.; Stricker, Phillip D.; Bornman, Maria S. (Riana); Hayes, Vanessa M. (Nature Research, 2022-09)
    Prostate cancer is characterized by considerable geo-ethnic disparity. African ancestry is a significant risk factor, with mortality rates across sub-Saharan Africa of 2.7-fold higher than global averages. The contributing ...
  • Alterations in the epigenetic machinery associated with prostate cancer health disparities 
    Craddock, Jenna; Jiang, Jue; Patrick, Sean Mark; Mutambirwa, Shingai B.A.; Stricker, Phillip D.; Bornman, Maria S. (Riana); Jaratlerdsiri, Weerachai; Hayes, Vanessa M. (MDPI, 2023-07)
    African ancestry is a significant risk factor for aggressive prostate cancer (PCa), with southern African ethnicity conferring a nearly 3-fold increased global risk for associated mortality. It is well understood that ...
  • Diagnosis of fusion genes using targeted RNA sequencing 
    Heyer, Erin E.; Deveson, Ira W.; Wooi, Danson; Selinger, Christina I.; Lyons, Ruth J.; Hayes, Vanessa M.; O’Toole, Sandra A.; Ballinger, Mandy L.; Gill, Devinder; Thomas, David M.; Mercer, Tim R.; Blackburn, James (Nature Publishing Group, 2019-03-27)
    Fusion genes are a major cause of cancer. Their rapid and accurate diagnosis can inform clinical action, but current molecular diagnostic assays are restricted in resolution and throughput. Here, we show that targeted ...
  • Discriminatory Gleason grade group signatures of prostate cancer : an application of machine learning methods 
    Mokoatle, Mpho; Mapiye, Darlington; Marivate, Vukosi; Hayes, Vanessa M.; Bornman, Maria S. (Riana) (Public Library of Science, 2022-06-09)
    One of the most precise methods to detect prostate cancer is by evaluation of a stained biopsy by a pathologist under a microscope. Regions of the tissue are assessed and graded according to the observed histological ...
  • DNA methylation profiles unique to Kalahari KhoeSan individuals 
    Goncearenco, Alexander; LaBarre, Brenna A.; Petrykowska, Hanna M.; Jaratlerdsiri, Weerachai; Bornman, Maria S. (Riana); Turner, Stephen D.; Hayes, Vanessa M.; Elnitski, Laura (Taylor and Francis, 2021)
    Genomes of KhoeSan individuals of the Kalahari Desert provide the greatest understanding of single nucleotide diversity in the human genome. Compared with individuals in industrialized environments, the KhoeSan have a ...
  • Metagenomic analysis reveals a rich bacterial content in high‐risk prostate tumors from African men 
    Feng, Ye; Jaratlerdsiri, Weerachai; Patrick, Sean Mark; Lyons, Ruth J.; Haynes, Anne‐Maree; Collins, Colin C.; Stricker, Phillip D.; Bornman, Maria S. (Riana); Hayes, Vanessa M. (Wiley, 2019-11)
    BACKGROUND : Inflammation is a hallmark of prostate cancer (PCa), yet no pathogenic agent has been identified. Men from Africa are at increased risk for both aggressive prostate disease and infection. We hypothesize that ...
  • Metagenomic and metatranscriptomic analysis of human prostate microbiota from patients with prostate cancer 
    Feng, Ye; Ramnarine, Varune Rohan; Bell, Robert; Volik, Stanislav; Davicioni, Elai; Hayes, Vanessa M.; Ren, Shancheng; Collins, Colin C. (BioMed Central, 2019-02-18)
    BACKGROUND : Prostate cancer (PCa) is the most common malignant neoplasm among men in many countries. Since most precancerous and cancerous tissues show signs of inflammation, chronic bacterial prostatitis has been hypothesized ...
  • MethylToSNP : identifying SNPs in Illumina DNA methylation array data 
    LaBarre, Brenna A.; Goncearenco, Alexander; Petrykowska, Hanna M.; Jaratlerdsiri, Weerachai; Bornman, Maria S. (Riana); Hayes, Vanessa M.; Elnitski, Laura (BioMed Central, 2019-12-20)
    BACKGROUND : Current array-based methods for the measurement of DNA methylation rely on the process of sodium bisulfite conversion to differentiate between methylated and unmethylated cytosine bases in DNA. In the absence of ...
  • Next generation mapping reveals novel large genomic rearrangements in prostate cancer 
    Jaratlerdsiri, Weerachai; Chan, Eva K.F.; Petersen, Desiree C.; Yang, Claire; Croucher, Peter I.; Bornman, Maria S. (Riana); Sheth, Palak; Hayes, Vanessa M. (Impact Journals, 2017-03-01)
    Complex genomic rearrangements are common molecular events driving prostate carcinogenesis. Clinical significance, however, has yet to be fully elucidated. Detecting the full range and subtypes of large structural variants ...
  • Optical mapping reveals a higher level of genomic architecture of chained fusions in cancer 
    Chan, Eva K.F.; Cameron, Daniel L.; Petersen, Desiree C.; Lyons, Ruth J.; Baldi, Benedetta F.; Papenfuss, Anthony T.; Thomas, David M.; Hayes, Vanessa M. (Cold Spring Harbor Laboratory Press, 2018)
    Genomic rearrangements are common in cancer, with demonstrated links to disease progression and treatment response. These rearrangements can be complex, resulting in fusions of multiple chromosomal fragments and generation ...
  • Prostate cancer in Southern Africa : does Africa hold untapped potential to add value to the current understanding of common disease? 
    Hayes, Vanessa M.; Bornman, Maria S. (Riana) (American Society of Clinical Oncology, 2017-03-21)
    Prostate cancer (PCa) is the most common cancer diagnosis in men from economically stable countries and is a leading cause of cancer-related death.1 However, the population with the highest reported incidence and ...
  • Reconstructing prehistoric African population structure 
    Skoglund, Pontus; Thompson, Jessica C.; Prendergast, Mary E.; Mittnik, Alissa; Sirak, Kendra; Hajdinjak, Mateja; Salie, Tasneem; Rohland, Nadin; Mallick, Swapan; Peltzer, Alexander; Heinze, Anja; Olalde, Iñigo; Ferry, Matthew; Harney, Eadaoin; Michel, Megan; Stewardson, Kristin; Cerezo-Román, Jessica I.; Chiumia, Chrissy; Crowther, Alison; Gomani-Chindebvu, Elizabeth; Gidna, Agness O.; Grillo, Katherine M.; Helenius, I. Taneli; Hellenthal, Garrett; Helm, Richard; Horton, Mark; López, Saioa; Mabulla, Audax Z.P.; Parkington, John; Shipton, Ceri; Thomas, Mark G.; Tibesasa, Ruth; Welling, Menno; Hayes, Vanessa M.; Kennett, Douglas J.; Ramesar, Raj; Meyer, Matthias; Pääbo, Svante; Patterson, Nick; Morris, Alan G.; Boivin, Nicole; Pinhasi, Ron; Krause, Johannes; Reich, David (Elsevier, 2017-09)
    We assembled genome-wide data from 16 prehistoric Africans. We show that the anciently divergent lineage that comprises the primary ancestry of the southern African San had a wider distribution in the past, contributing ...
  • A review and comparative study of cancer detection using machine learning : SBERT and SimCSE application 
    Mokoatle, Mpho; Marivate, Vukosi; Mapiye, Darlington; Bornman, Maria S. (Riana); Hayes, Vanessa M. (BMC, 2023-03-23)
    BACKGROUND : Using visual, biological, and electronic health records data as the sole input source, pretrained convolutional neural networks and conventional machine learning methods have been heavily employed for the ...
  • Revised timeline and distribution of the earliest diverged human maternal lineages in Southern Africa 
    Chan, Eva K.F.; Hardie, Rae-Anne; Petersen, Desiree C.; Beeson, Karen; Bornman, Maria S. (Riana); Smith, Andrew B.; Hayes, Vanessa M. (Public Library of Science, 2015-03-25)
    The oldest extant human maternal lineages include mitochondrial haplogroups L0d and L0k found in the southern African click-speaking forager peoples broadly classified as Khoesan. Profiling these early mitochondrial lineages ...
  • Spectrum of mitochondrial genomic variation and associated clinical presentation of prostate cancer in South African men 
    McCrow, John P.; Petersen, Desiree C.; Louw, Melanie; Chan, Eva K. F.; Harmeyer, Katherine; Vecchiarelli, Stefano; Lyons, Ruth J.; Bornman, Maria S. (Riana); Hayes, Vanessa M. (Wiley, 2016-03)
    BACKGROUND : Prostate cancer incidence and mortality rates are significantly increased in African–American men, but limited studies have been performed within Sub–Saharan African populations. As mitochondria control ...
  • TMPRSS2-ERG fusions linked to prostate cancer racial health disparities : a focus on Africa 
    Blackburn, James; Vecchiarelli, Stefano; Heyer, Erin E.; Patrick, Sean Mark; Lyons, Ruth J.; Jaratlerdsiri, Weerachai; Van Zyl, Smit; Bornman, Maria S. (Riana); Mercer, Tim R.; Hayes, Vanessa M. (Wiley, 2019-07)
    BACKGROUND : The androgen‐regulated gene TMPRSS2 to the ETS transcription factor gene ERG fusion is the most common genomic alteration acquired during prostate tumorigenesis and biased toward men of European ancestry. ...