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Browsing Research Articles (Anatomy) by UP Author "Gaspar, Anabella Regina Marques"
Now showing items 1-13 of 13
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Malan, Melissa; Serem, June Cheptoo; Bester, Megan Jean; Neitz, Albert Walter Herman; Gaspar, Anabella Regina Marques (Wiley, 2016-01)Antimicrobial peptides (AMPs) are small, cationic peptides that possess a large spectrum of bioactivities, including antimicrobial, anti-inflammatory and antioxidant activities. Several AMPs are known to inhibit ...
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Ibrahim, Mohammed Auwal; Serem, June Cheptoo; Abdullahi, Aliyu Dantani; Aminu, Suleiman; Aliyu, Abubakar Babando; Musa, Aliyu Muhammad; Musa, Bashir; Bester, Megan; Gaspar, A.R.M. (Anabella Regina Marques) (Springer, 2023-04)The multifactorial nature of type 2 diabetes mellitus (T2DM) has driven a need to discover multifunctional antidiabetic peptides preferably from functional food sources for possible application as antidiabetic supplements. ...
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Ibrahim, Mohammed Auwal; Serem, June Cheptoo; Bester, Megan Jean; Gaspar, Anabella Regina Marques (Elsevier, 2020-10)Type 2 diabetes is a multifactorial disease and drugs with multifunctional properties are required. The peptide, SQSPA, was reported to be a potent and gastrointestinally stable α-glucosidase inhibitory peptide. In this ...
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Taute, Helena; Bester, Megan Jean; Gaspar, Anabella Regina Marques (Wiley, 2019-04)Antimicrobial peptides (AMPs), Os and Os‐C, have been identified as multifunctional peptides with antibacterial, antiendotoxin, and anti‐inflammatory properties. For further development of Os and Os‐C as therapeutic peptides, ...
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Rabie, E.; Serem, June Cheptoo; Oberholzer, Hester Magdalena; Gaspar, Anabella Regina Marques; Bester, Megan Jean (Taylor and Francis, 2016-03)Antibacterial activity of honey is due to the presence of methylglyoxal (MGO), H2O2, bee defensin as well as polyphenols. High MGO levels in manuka honey are the main source of antibacterial activity. Manuka honey has ...
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Taute, Helena; Bester, Megan Jean; Neitz, Albert Walter Herman; Gaspar, Anabella Regina Marques (Elsevier, 2015-09)Os and Os-C are two novel antimicrobial peptides, derived from a tick defensin, which have been shown to have a larger range of antimicrobial activity than the parent peptide, OsDef2. The aim of this study was to determine ...
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Ibrahim, Mohammed Auwal; Serem, June Cheptoo; Bester, Megan Jean; Neitz, Albert Walter Herman; Gaspar, Anabella Regina Marques (Elsevier, 2019-02)Antidiabetic agents with multiple targets have the greatest pharmaceutical potential. In this study, three α-glucosidase inhibitory peptides, PFP, YPL and YPG, were investigated for additional antidiabetic targets viz.; ...
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Ibrahim, Mohammed Auwal; Serem, June Cheptoo; Bester, Megan Jean; Neitz, Albert Walter Herman; Gaspar, Anabella Regina Marques (Springer, 2020-12)Type 2 diabetes mellitus (T2DM) is a multifactorial disease that requires multiple therapeutic strategies for its management. Bioactive peptides with multiple anti-diabetic targets are attractive therapeutic molecules. The ...
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Ibrahim, Mohammed Auwal; Bester, Megan Jean; Neitz, Albert Walter Herman; Gaspar, Anabella Regina Marques (Elsevier, 2018-11)Treatment of type 2 diabetes is achieved through the inhibition of carbohydrate hydrolyzing enzymes such as α-glucosidase and α-amylase. The present study was conducted to identify novel α-glucosidase inhibitory peptides ...
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Prinsloo, Lezaan; Naidoo, Alex; Serem, June Cheptoo; Taute, Helena; Sayed, Yasien; Bester, Megan Jean; Neitz, Albert Walter Herman; Gaspar, Anabella Regina Marques (Wiley, 2013-05)Tick defensins may serve as templates for the development of multifunctional peptides. The purpose of this study was to evaluate shorter peptides derived from tick defensin isoform 2 (OsDef2) in terms of their antibacterial, ...
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Ibrahim, Mohammed Auwal; Bester, Megan Jean; Neitz, Albert Walter Herman; Gaspar, Anabella Regina Marques (Wiley, 2018-02)Bioactive peptides are emerging as promising class of drugs that could serve as α-glucosidase inhibitors for the treatment of type 2 diabetes. This article identifies structural and physicochemical requirements for the ...
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Ibrahim, Mohammed Auwal; Serem, June Cheptoo; Bester, Megan Jean; Neitz, Albert Walter Herman; Gaspar, Anabella Regina Marques (Bentham Science, 2019-07)BACKGROUND : Peptide-based therapeutics offer a unique avenue for the development of novel agents for the treatment of diabetes mellitus including α-glucosidase inhibitors. The peptide, SQSPA, was reported to possess to α ...
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Ibrahim, Mohammed Auwal; Bester, Megan Jean; Neitz, Albert Walter Herman; Gaspar, Anabella Regina Marques (Springer, 2019-06)In silico analysis was used to evaluate storage proteins from plant tubers as potential precursors of bioactive peptides after simulated gastrointestinal digestion. Proteins derived from potato (patatins), sweet potato ...
Now showing items 1-13 of 13