Scanning electron microscopy investigation of fibrin networks after thermal injury

Show simple item record

dc.contributor.author Pretorius, Etheresia
dc.contributor.author Olivier, Jeane
dc.contributor.author Oberholzer, Hester Magdalena
dc.contributor.author Van der Spuy, Wendy Jeannette
dc.date.accessioned 2011-08-03T06:15:21Z
dc.date.available 2011-08-03T06:15:21Z
dc.date.issued 2011-07
dc.description.abstract Injury due to burning is known to impact on coagulation and haemostasis by disturbing the coagulation cascade and is also associated with impaired fibrinolysis. Also, venous thrombosis, pulmonary embolism and hypercoagulability are common during thermal injury. Using a Wistar albino rat model, we investigated in this study whether burn injury affects the ultrastructure of the fibrin networks. A typical fibrin network will contain mostly major, thick fibres with minor, thin fibres distributed amongst them. We found that the clot architecture changes after burn injury, showing more prominent minor, thin fibres in a netted appearance. Also, the clot showed areas of matted fibrin. We suggest that the thrombotic events associated with burn injury are due to the thickened and netlike areas formed when thrombin activates the coagulation cascade. This is due to impaired fibrinolysis activities, causing the resulting fibrin clots not to be successfully disseminated. Small fragments of these netted, clumped areas may therefore break loose and lead to thrombotic events after burn injuries. The current study therefore provided morphological evidence for thrombotic events associated with burn injury. en_US
dc.description.uri http://www.ojvr.org en_US
dc.identifier.citation Pretorius, E, Olivier, J, Oberholzer, HM & Van der Spuy, WJ, 2011, ‘Scanning electron microscopy investigation of fibrin networks after thermal injury’, Onderstepoort Journal of Veterinary Research 78(1), Art. #244, 4 pages. doi:10.4102/ojvr.v78i1.244 en_US
dc.identifier.issn 0030-2465
dc.identifier.other 10.4102/ojvr.v78i1.244
dc.identifier.uri http://hdl.handle.net/2263/16969
dc.language.iso en en_US
dc.publisher Agricultural Research Council, ARC-OVI and the University of Pretoria en_US
dc.rights © 2011. The Authors. Licensee: OpenJournals Publishing. This work is licensed under the Creative Commons Attribution License. en_US
dc.subject Scanning en_US
dc.subject Fibrin networks en_US
dc.subject.lcsh Burns and scalds -- Research -- South Africa en
dc.subject.lcsh Thrombophlebitis -- Research en
dc.subject.lcsh Ultrastructure (Biology) en
dc.subject.lcsh Pulmonary embolism en
dc.subject.lcsh Fibrinogen polymorphisms en
dc.title Scanning electron microscopy investigation of fibrin networks after thermal injury en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record