Although the inclusion of the cationic amphiphilic, anti-mycobacterial agent, clofazimine,
in the chemotherapeutic regimens of patients with multidrug-resistant tuberculosis
(TB) has contributed to improved outcomes, ...
Anderson, Ronald; Nel, Jan Gert; Feldman, Charles(MDPI Publishing, 2018-04-11)
Pneumolysin (PLY), a member of the family of Gram-positive bacterial,
cholesterol-dependent, -barrel pore-forming cytolysins, is the major protein virulence factor of the
dangerous respiratory pathogen, Streptococcus ...
Tintinger, Gregory Ronald; Theron, Annette J.; Steel, Helen C.; Cholo, Moloko C.; Nel, Jan Gert; Feldman, Charles; Anderson, Ronald(MDPI, 2021-02-26)
Although bedaquiline has advanced the treatment of multidrug-resistant tuberculosis (TB),
concerns remain about the cardiotoxic potential of this agent, albeit by unexplored
mechanisms. Accordingly, we have investigated ...
