Prevalence and diversity of rotavirus strains in children with acute diarrhea from rural communities in the Limpopo Province South Africa, from 1998 to 2000

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dc.contributor.author Potgieter, Natasha
dc.contributor.author De Beer, Mariet C.
dc.contributor.author Taylor, Maureen B.
dc.contributor.author Steele, A.D. (Andrew Duncan)
dc.date.accessioned 2011-02-07T08:40:36Z
dc.date.available 2011-02-07T08:40:36Z
dc.date.issued 2010
dc.description.abstract BACKROUND: Data regarding the prevalence and molecular epidemiology of rotavirus infection in rural areas of Africa are limited. In this study the prevalence and genetic diversity of rotaviruses in a rural South African setting were investigated. METHODS: During June 1998 to June 2000, 420 stool specimens were collected from children with acute diarrhea who visited primary health care clinics in the rural Vhembe region, Limpopo Province, South Africa. Group A rotaviruses were detected by enzyme-linked immunosorbent assay, and the G and P types were determined by reverse-transcription polymerase chain reaction. RESLUTS: Of the 420 specimens, 111 (26.4%) were positive for group A rotavirus; P[6]G1 strains predominated (32.4%), followed by P[8]G1 (13.5%), P[6]G9 (4.5%), P[4]G8 (3.6%), P[4]G1 (3.6%), P[6]G8 (3.6%), and P[6]G2 (2.7%). Dual infections, with 11 P type, were seen in 33 (37.1%) of the positive specimens. CONCLUSIONS: The unusual serotype and genotype combinations of rotavirus circulating in the rural communities of the Limpopo Province highlight the need for more studies to monitor the geographic distribution of rotavirus strains in rural African settings. en_US
dc.identifier.citation Potgieter, N, De Beer, MC, Taylor, MB & Steele, AD 2010, 'Prevalence and diversity of rotavirus strains in children with acute diarrhea from rural communities in the Limpopo Province, South Africa, from 1998 to 2000', Journal of Infectious Diseases, vol. 202, suppl. , S148-S155. [http://www.journals.uchicago.edu/toc/jid/current] en_US
dc.identifier.issn 0022-1899
dc.identifier.uri http://hdl.handle.net/2263/15833
dc.language.iso en en_US
dc.publisher University of Chicago Press en_US
dc.rights © 2010 by the Infectious Diseases Society of America. All rights reserved. en_US
dc.subject Prevalence and diversity en_US
dc.subject Rotavirus strains en_US
dc.subject Children en_US
dc.subject Acute diarrhea en_US
dc.subject Rural communities en_US
dc.subject Limpopo Province, South Africa en_US
dc.subject.lcsh Viruses
dc.title Prevalence and diversity of rotavirus strains in children with acute diarrhea from rural communities in the Limpopo Province South Africa, from 1998 to 2000 en_US
dc.type Article en_US


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