Prevalence and diversity of rotavirus strains in children with acute diarrhea from rural communities in the Limpopo Province South Africa, from 1998 to 2000

dc.contributor.authorPotgieter, Natasha
dc.contributor.authorDe Beer, Mariet C.
dc.contributor.authorTaylor, Maureen B.
dc.contributor.authorSteele, Andrew Duncan
dc.date.accessioned2011-02-07T08:40:36Z
dc.date.available2011-02-07T08:40:36Z
dc.date.issued2010
dc.description.abstractBACKROUND: Data regarding the prevalence and molecular epidemiology of rotavirus infection in rural areas of Africa are limited. In this study the prevalence and genetic diversity of rotaviruses in a rural South African setting were investigated. METHODS: During June 1998 to June 2000, 420 stool specimens were collected from children with acute diarrhea who visited primary health care clinics in the rural Vhembe region, Limpopo Province, South Africa. Group A rotaviruses were detected by enzyme-linked immunosorbent assay, and the G and P types were determined by reverse-transcription polymerase chain reaction. RESLUTS: Of the 420 specimens, 111 (26.4%) were positive for group A rotavirus; P[6]G1 strains predominated (32.4%), followed by P[8]G1 (13.5%), P[6]G9 (4.5%), P[4]G8 (3.6%), P[4]G1 (3.6%), P[6]G8 (3.6%), and P[6]G2 (2.7%). Dual infections, with 11 P type, were seen in 33 (37.1%) of the positive specimens. CONCLUSIONS: The unusual serotype and genotype combinations of rotavirus circulating in the rural communities of the Limpopo Province highlight the need for more studies to monitor the geographic distribution of rotavirus strains in rural African settings.en_US
dc.identifier.citationPotgieter, N, De Beer, MC, Taylor, MB & Steele, AD 2010, 'Prevalence and diversity of rotavirus strains in children with acute diarrhea from rural communities in the Limpopo Province, South Africa, from 1998 to 2000', Journal of Infectious Diseases, vol. 202, suppl. , S148-S155. [http://www.journals.uchicago.edu/toc/jid/current]en_US
dc.identifier.issn0022-1899
dc.identifier.urihttp://hdl.handle.net/2263/15833
dc.language.isoenen_US
dc.publisherUniversity of Chicago Pressen_US
dc.rights© 2010 by the Infectious Diseases Society of America. All rights reserved.en_US
dc.subjectPrevalence and diversityen_US
dc.subjectRotavirus strainsen_US
dc.subjectChildrenen_US
dc.subjectAcute diarrheaen_US
dc.subjectRural communitiesen_US
dc.subjectLimpopo Province, South Africaen_US
dc.subject.lcshViruses
dc.titlePrevalence and diversity of rotavirus strains in children with acute diarrhea from rural communities in the Limpopo Province South Africa, from 1998 to 2000en_US
dc.typeArticleen_US

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