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Browsing Research Articles (University of Pretoria) by UP Author "Ellero, Andrea Antonio"

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Characterization and reproducibility of HepG2 hanging drop spheroids toxicology in vitro

Hurrell, Tracey; Ellero, Andrea Antonio; Masso, Zelie Flavienne; Cromarty, Allan Duncan (Elsevier, 2018-08)

Hepatotoxicity remains a major challenge in drug development despite preclinical toxicity screening using hepatocytes of human origin. To overcome some limitations of reproducing the hepatic phenotype, more structurally ...
Continual proteomic divergence of HepG2 cells as a consequence of long-term spheroid culture

Ellero, Andrea Antonio; Van den Bout, Iman; Vlok, Mare; Cromarty, Allan Duncan; Hurrell, Tracey (Nature Research, 2021-05)

Three-dimensional models are considered a powerful tool for improving the concordance between in vitro and in vivo phenotypes. However, the duration of spheroid culture may infuence the degree of correlation between these ...
Social media and COVID-19-perceptions and public deceptions of ivermectin, colchicine and hydroxychloroquine : lessons for future pandemics

Schellack, Natalie; Strydom, Morne A.; Pepper, Michael Sean; Herd, Candice Lee; Hendricks, Candice Laverne; Bronkhorst, Elmien; Meyer, Johanna C.; Padayachee, Neelaveni; Bangalee, Varsha; Truter, Ilse; Ellero, Andrea Antonio; Myaka, Thulisa; Naidoo, Elysha; Godman, Brian (MDPI, 2022-04)

The capacity for social media to influence the utilization of re-purposed medicines to manage COVID-19, despite limited availability of safety and efficacy data, is a cause for concern within health care systems. This ...

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Browsing Research Articles (University of Pretoria) by UP Author "Ellero, Andrea Antonio"

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