Browsing Research Articles (University of Pretoria) by Subject "Vaccine"

Browsing Research Articles (University of Pretoria) by Subject "Vaccine"

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  • Activation of canine, mouse and human TLR2 and TLR4 by inactivated Leptospira vaccine strains 
    Novak, Andreja; Pupo, Elder; Esther van’t Veld; Rutten, Victor P.M.G.; Broere, Femke; Sloots, Arjen (Frontiers Media S.A., 2022-03-21)
    Canine Leptospira vaccines contain inactivated strains of pathogenic Leptospira, the causative agents of leptospirosis. For an effective response to vaccination, activation of the innate immune system via pattern recognition ...
  • Ad26.COV2.S breakthrough infections induce high titers of neutralizing antibodies against Omicron and other SARS-CoV-2 variants of concern 
    Kitchin, Dale; Richardson, Simone I.; Van der Mescht, Mieke Adri; Motlou, Thopisang; Mzindle, Nonkululeko; Moyo-Gwete, Thandeka; Makhado, Zanele; Ayres, Frances; Manamela, Nelia P.; Spencer, Holly; Lambson, Bronwen; Oosthuysen, Brent; Kaldine, Haajira; Du Pisanie, Marizane; Mennen, Mathilda; Skelem, Sango; Williams, Noleen; Ntusi, Ntobeko A.B.; Burgers, Wendy A.; Gray, Glenda G.; Bekker, Linda-Gail; Boswell, Michael T.; Rossouw, Theresa M.; Ueckermann, Veronica; Moore, Penny L. (Cell Press, 2022-03-15)
    The Janssen (Johnson & Johnson) Ad26.COV2.S non-replicating viral vector vaccine has been widely deployed for COVID-19 vaccination programs in resource-limited settings. Here we confirm that neutralizing and binding ...
  • Analysis and insights into recombination signals in lumpy skin disease virus recovered in the field 
    Sprygin, Alexander; Babin, Yurii; Pestova, Yana; Kononova, Svetlana; Wallace, David Brian; Van Schalkwyk, Antoinette; Byadovskaya, Olga; Diev, Vyacheslav; Lozovoy, Dmitry; Kononov, Alexander (Public Library of Science, 2018-12-12)
    Wide spread incidences of vaccine-like strains of lumpy skin disease virus (LSDV) have recently been reported in a Russian region with a neighboring country that actively vaccinate with a live attenuated LSD vaccine. The ...
  • Backward bifurcation analysis of epidemic model with partial immunity 
    Anguelov, Roumen; Garba, Salisu M.; Usaini, Salisu (Elsevier, 2014-11)
    This paper presents a two stage SIS epidemic model in animal population with bovine tuberculosis (BTB) in African buffalo as a guiding example. The proposed model is rigorously analyzed. The analysis reveals that the ...
  • Barriers affecting COVID‑19 vaccination in Phalombe District, Malawi : a qualitative study 
    Chimatiro, C.S.; Hajison, P.; Jella, C.D.; Tshotetsi, Lumbani; Mpachika-Mfip, F. (South African Medical Association, 2023-04)
    BACKGROUND : In Malawi, only 1 072 229 people out of a national target population of 13 546 324 had received at least one dose of the AstraZeneca COVID‑19 vaccine by 26 December 2021, and only 672 819 people were classified ...
  • Cattle tick vaccine researchers join forces in CATVAC 
    Schetters, Theo; Bishop, Richard P.; Crampton, Michael; Kopacek, Petr; Lew-Tabor, Alicja; Maritz-Olivier, Christine; Miller, Robert; Mosqueda, Juan; Patarroyo, Joaquin; Rodriguez-Valle, Manuel; Scoles, Glen A.; De la Fuente, Jose (BioMed Central, 2016-02-24)
    A meeting sponsored by the Bill & Melinda Gates Foundation was held at the Avanti Hotel, Mohammedia, Morocco, July 14–15, 2015. The meeting resulted in the formation of the Cattle Tick Vaccine Consortium (CATVAC).
  • CD4+ T cell responses to Toxoplasma gondii are a double-edged sword 
    El Bissati, Kamal; Krishack, Paulette A.; Zhou, Ying; Weber, Christopher R.; Lykins, Joseph; Jankovic, Dragana; Edelblum, Karen L.; Fraczek, Laura; Grover, Harshita; Chentoufi, Aziz Alami; Singh, Gurminder; Reardon, Catherine; Dubey, J.P.; Reed, Steve; Alexander, Jeff; Sidney, John; Sette, Alessandro; Shastri, Nilabh; McLeod, Rima (MDPI, 2023-09-14)
    CD4+ T cells have been found to play critical roles in the control of both acute and chronic Toxoplasma infection. Previous studies identified a protective role for the Toxoplasma CD4+ T celleliciting peptide AS15 ...
  • A combination of antibodies against Bm86 and Subolesin inhibits engorgement of Rhipicephalus australis (formerly Rhipicephalus microplus) larvae in vitro 
    Trentelman, Jos J.A.; Teunissen, Hendry; Kleuskens, Jos A.G.M.; Van de Crommert, Jos; De la Fuente, Jose; Hovius, Joppe W. R.; Schetters, Theo (BioMed Central, 2019-07)
    BACKGROUND: Rhipicephalus microplus is a hard tick species that has a high impact on cattle health and production in tropical and subtropical regions. Recently, ribosomal DNA and morphological analysis resulted in the ...
  • Complete genome sequences of virus strains isolated from bottle A of the South African live attenuated bluetongue virus vaccine 
    Coetzee, Peter; Guthrie, Alan John; Ebersohn, Karen; Maclachlan, James N.; Ismail, Arshad; Van Schalkwyk, Antoinette; Venter, Estelle Hildegard (American Society for Microbiology, 2020-05-28)
    This is a report of the complete genome sequences of plaque-selected isolates of five virus strains included in bottle A of the South African Onderstepoort Biological Products commercial live attenuated bluetongue virus vaccine.
  • COVID-19 vaccine roll-out in South Africa and Zimbabwe : urgent need to address community preparedness, fears and hesitancy 
    Dzinamarira, Tafadzwa; Nachipo, Brian; Phiri, Bright; Musuka, Godfrey (MDPI, 2021-03)
    South Africa became one of the first African countries to receive the COVID-19 vaccine. As the rest of Africa prepares to receive COVID-19 vaccines, most countries in Africa have set up nationallevel coordination committees ...
  • Deep sequencing of the HIV‑1 polymerase gene for characterisation of cytotoxic T‑lymphocyte epitopes during early and chronic disease stages 
    Nkone, Paballo; Loubser, Shayne; Quinn, Thomas C.; Redd, Andrew D.; Ismail, Arshad; Tiemessen, Caroline T.; Mayaphi, Simnikiwe Horatious (BMC, 2022-03)
    BACKGROUND : Despite multiple attempts, there is still no effective HIV-1 vaccine available. The HIV-1 polymerase (pol) gene is highly conserved and encodes cytotoxic T-lymphocyte (CTL) epitopes. The aim of the study was ...
  • Directed genetic modification of African horse sickness virus by reverse genetics 
    Vermaak, Elaine; Paterson, Duncan J.; Conradie, Andele M.; Theron, Jacques (AOSIS OpenJournals, 2015)
    African horse sickness virus (AHSV), a member of the Orbivirus genus in the family Reoviridae, is an arthropod-transmitted pathogen that causes a devastating disease in horses with a mortality rate greater than 90%. ...
  • EEHV1A glycoprotein B subunit vaccine elicits humoral and cell-mediated immune responses in mice 
    Clinton, Jennifer L. Spencer; Hoornweg, Tabitha E.; Tan, Jie; Peng, Rongsheng; Schaftenaar, Willem; Rutten, Victor P.M.G.; De Haan, Cornelis A.M.; Ling, Paul D. (Elsevier, 2022-08)
    Asian elephants are an endangered species facing many threats, including severe hemorrhagic disease (HD) caused by the elephant endotheliotropic herpesvirus (EEHV). EEHV-HD is the leading cause of death in captive juvenile ...
  • Efficacy of SAT2 foot-and-mouth disease vaccines formulated with Montanide ISA 206B and Quil-A Saponin adjuvants 
    Rathogwa, Ntungufhadzeni Maclaughlin; Scott, Katherine A.; Opperman, Pamela Anne; Jacques, Theron,; Maree, Francois F. (MDPI, 2021-09)
    The effective control of foot-and-mouth disease (FMD) relies strongly on the separation of susceptible and infected livestock or susceptible livestock and persistently infected wildlife, vaccination, and veterinary sanitary ...
  • Exploiting Pan Influenza A and Pan Influenza B pseudotype libraries for efficient vaccine antigen selection 
    Del Rosario, Joanne Marie M.; Da Costa, Kelly A.S.; Asbach, Benedikt; Ferrara, Francesca; Ferrari, Matteo; Wells, David A.; Mann, Gurdip Singh; Ameh, Veronica O.; Sabeta, Claude Taurai; Banyard, Ashley C.; Kinsley, Rebecca; Scott, Simon D.; Wagner, Ralf; Heeney, Jonathan L.; Carnell, George W.; Temperton, Nigel J. (MDPI, 2021-07)
    We developed an influenza hemagglutinin (HA) pseudotype library encompassing Influenza A subtypes HA1-18 and Influenza B subtypes (both lineages) to be employed in influenza pseudotype microneutralization (pMN) assays. ...
  • Exploring a community's understanding of HIV vaccine-induced seropositivity in a South African research setting 
    Malahleha, M.; Dilraj, A.; Jean, J.; Morar, N.S.; Dietrich, J.J.; Ross, M.; Mbatsane, E.; Keefer, M.C.; Ahmed, Khatija (South African Medical Association, 2023-01)
    BACKGROUND. The high HIV prevalence and incidence in South Africa makes it suitable for recruitment of participants for large-scale HIV preventive vaccine trials. However, fear of vaccine-induced seropositivity (VISP) may ...
  • Generation of a soluble African horse sickness virus VP7 protein capable of forming core-like particles 
    Bekker, Shani; Huismans, H. (Henk), 1942-; Van Staden, Vida (MDPI, 2022-07-26)
    A unique characteristic of the African horse sickness virus (AHSV) major core protein VP7 is that it is highly insoluble, and spontaneously forms crystalline particles in AHSV-infected cells and when expressed in vitro. ...
  • A glycosylated recombinant subunit candidate vaccine consisting of Ehrlichia ruminantium major antigenic protein1 induces specific humoral and Th1 type cell responses in sheep 
    Faburay, Bonto; McGill, Jodi; Jongejan, Frans (Public Library of Science, 2017-09-28)
    Heartwater, or cowdriosis, is a tick-borne disease of domestic and wild ruminants that is endemic in the Caribbean and sub-Saharan Africa. The disease is caused by an intracellular pathogen, Ehrlichia ruminantium and may ...
  • The health impact of rabies in Haiti and recent developments on the path toward elimination, 2010–2015 
    Wallace, Ryan; Etheart, Melissa; Ludder, Fleurinord; Augustin, Pierre; Fenelon, Natael; Franka, Richard; Crowdis, Kelly; Dely, Patrick; Adrien, Paul; Pierre-Louis, J.; Osinubi, Modupe; Orciari, Lillian; Vigilato, Marco; Blanton, Jesse; Patel, Roopal; Lowrance, David; Liverdieu, Andrecy; Coetzer, Andre; Boone, John; Lindenmayer, Joanne; Millien, M. (American Society of Tropical Medicine and Hygiene, 2017)
    Haiti, a Caribbean country of 10.5 million people, is estimated to have the highest burden of caninemediated human rabies deaths in the Western Hemisphere, and one of the highest rates of human rabies deaths in the world. ...
  • Hepatitis B and Hepatitis C viruses- revisited 
    Kungoane, Tsholofelo (South African Dental Association, 2018-03)
    Dental health care personnel are at increased risk of acquiring blood-borne infections including hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV). Infection is acquired through ...