Hospital and community isolates of uropathogens at a tertiary hospital in South Africa

Show simple item record Habte, T.M. Dube, S. Ismail, Nazir Ahmed Hoosen, Anwar Ahmed 2009-09-23T09:58:48Z 2009-09-23T09:58:48Z 2009-08
dc.description.abstract AIM: To investigate the profile of common uropathogens isolated from urine specimens submitted to the diagnostic microbiology laboratory at a tertiary teaching hospital and assess their antimicrobial susceptibility patterns to commonly used antimicrobial agents. METHODS: We conducted a retrospective analysis of laboratory reports for all urine specimens submitted for investigations over a 1-year period. Isolates were tested by means of the Kirby-Bauer disc diffusion method for susceptibility to amoxicillin, ciprofloxacin, gentamicin, co-trimoxazole and nitrofurantoin, and for extended-spectrum beta-lactamase (ESBL) production. RESULTS: Out of the total specimens (N =2 203) received over the 1-year study period, 51.1% (1 126) of the urine samples were culture-positive, the majority (65.4%) having come from females. The most common isolate was Escherichia coli (39.0%) followed by Klebsiella species (20.8%) and Enterococcus faecalis (8.2%). The Gram-negative isolates displayed a very high level of resistance to amoxicillin (range 43 - 100%) and co-trimoxazole (range 29 - 90%), whereas resistance to gentamicin (range 0 - 50%) and ciprofloxacin (range 0 - 33%) was lower. E. coli isolates were susceptible to nitrofurantoin (94%), and ESBL production was significantly higher (p=0.01) in the hospital isolates, compared with those from the community referral sites. CONCLUSIONS: The culture-positive rate for uropathogens was high, with a greater incidence among females. E. coli was the most common aetiological agent identified, and remained susceptible to nitrofurantoin. Resistance levels to amoxicillin and co-trimoxazole were very high for all Gram-negative isolates, and it is recommended that these antibiotics should not be used for the empiric treatment of urinary tract infections. en_US
dc.identifier.citation Habte, TM, Dube, S, Ismail, N & Hoosen, AA 2009, 'Hospital and community isolates of uropathogens at a tertiary hospital in South Africa', South African Medical Journal, vol. 99, no. 8, pp. 584-587. [] en_US
dc.identifier.issn 0038-3469
dc.language.iso en en_US
dc.publisher Health and Medical Publishing Group en_US
dc.rights Health and Medical Publishing Group en_US
dc.subject Uropathogens en
dc.subject.lcsh Urine -- Analysis en
dc.subject.lcsh Pathogenic microorganisms -- Identification en
dc.subject.lcsh Anti-infective agents -- South Africa en
dc.subject.lcsh Hospitals -- South Africa en
dc.subject.lcsh Diagnostic microbiology -- South Africa en
dc.title Hospital and community isolates of uropathogens at a tertiary hospital in South Africa en_US
dc.type Article en_US

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