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Permanent URI for this collectionhttp://hdl.handle.net/2263/91695

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    Metastatic MelanomaL Striving to stop the spread
    (VYT, 2022) Basson, Charlise
    Melanoma is the leading cause of death from skin cancer, due to its ability to metastasise (spread). In my study, I tested two compounds, namely L-kynurenine and quinolinic acid on melanoma cells. It was found that both compounds reduced cell growth, activated cell death,induced structural damage and altered organelles (components in cells) that link to cell death in melanoma cells. In addition, L-kynurenine also activated molecules associated with cell death and was shown to be the most potent compound. The next step is to investigate the effects of these compounds on cancer adhesion, which is implicated in cancer metastasis.
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    Effectiveness of a system thinking visualization tool in first-year Chemistry
    (VYT, 2022) Reynders, Micke
    Chemistry has contributed to irreversible global issues. We need to change our approach to chemistry education and equip students with these key competencies so that they can take sustainable action. This study focused on developing systems thinking in first year chemistry students. An ST activity where students learned about this molecule used in laundry detergents and its impact in the economy, the environment and society was designed. Students had to expand this systems oriented concept map to apply their systems thinking skills to visualize the complex interconnections of these subsystems. The visualization tool was effective as students zoomed out of the chemistry to recognized its real-world implications to understand its interconnectedness. This research is significant as learning in chemistry can be made more meaningful and can inspire students to take ownership.