Browsing by Author "Omar, Shaheed Vally"

Browsing by Author "Omar, Shaheed Vally"

Sort by: Order: Results:

  • Laboratory evaluation of a specimen transport medium for downstream molecular processing of sputum samples to detect Mycobacterium tuberculosis 
    Omar, Shaheed Vally; Peters, Remco P.H.; Ismail, Nazir Ahmed; Dreyer, Andries W.; Said, Mohamed; Gwala, Thabisile; Ismail, Nabila; Fourie, P.B. (Petrus Bernardus) (Elsevier, 2015-10)
    BACKGROUND : Modern molecular-based approaches for the detection of Mycobacterium tuberculosis in sputum samples promise quicker and more accurate detection of cases. However, processing sputum samples at central diagnostic ...
  • MDR M. tuberculosis outbreak clone in Eswatini missed by Xpert has elevated bedaquiline resistance dated to the pre-treatment era 
    Beckert, Patrick; Sanchez-Padilla, Elisabeth; Merker, Matthias; Dreyer, Viola; Kohl, Thomas A.; Utpatel, Christian; Köser, Claudio U.; Barilar, Ivan; Ismail, Nazir Ahmed; Omar, Shaheed Vally; Klopper, Marisa; Warren, Robin M.; Hoffmann, Harald; Maphalala, Gugu; Ardizzoni, Elisa; De Jong, Bouke C.; Kerschberger, Bernhard; Schramm, Birgit; Andres, Sonke; Kranzer, Katharina; Maurer, Florian P.; Bonnet, Maryline; Niemann, Stefan (BioMed Central, 2020-12)
    BACKGROUND: Multidrug-resistant (MDR) Mycobacterium tuberculosis complex strains not detected by commercial molecular drug susceptibility testing (mDST) assays due to the RpoB I491F resistance mutation are threatening ...
  • Modeling missing cases and transmission links in networks of extensively drug-resistant tuberculosis in KwaZulu-Natal, South Africa 
    Nelson, Kristin N.; Gandhi, Neel R.; Mathema, Barun; Lopman, Benjamin A.; Brust, James C.M.; Auld, Sara C.; Ismail, Nazir Ahmed; Omar, Shaheed Vally; Brown, Tyler S.; Allana, Salim; Campbell, Angie; Moodley, Pravi; Mlisana, Koleka; Shah, N. Sarita; Jenness, Samuel M. (Oxford University Press, 2020-07)
    Patterns of transmission of drug-resistant tuberculosis (TB) remain poorly understood, despite over half a million incident cases worldwide in 2017. Modeling TB transmission networks can provide insight into drivers of ...
  • Molecular characterization and second-line antituberculosis drug resistance patterns of multidrug-resistant mycobacterium tuberculosis isolates from the Northern Region of South Africa 
    Said, Halima Mohammed; Kock, Marleen M.; Ismail, Nazir Ahmed; Mphahlele, Matsie Theodora; Baba, Kamaldeen A.; Omar, Shaheed Vally; Osman, Ayman Gassim Elamin; Hoosen, Anwar Ahmed; Ehlers, Marthie Magdaleen (American Society for Microbiology, 2012-09)
    Despite South Africa being one of the high-burden multidrug-resistant tuberculosis (MDR-TB) countries, information regarding the population structure of drug-resistant Mycobacterium tuberculosis strains is limited from ...
  • Molecular detection of Mycobacterium tuberculosis from sputum transported in PrimeStore(®) from rural settings 
    Daum, Luke T.; Peters, Remco P.H.; Fourie, P.B. (Petrus Bernardus); Jonkman, K.; Worthy, Sue A.; Rodriguez, John D.; Ismail, Nazir Ahmed; Omar, Shaheed Vally; Fischer, Gerald W. (International Union Against Tuberculosis and Lung Disease, 2015-05)
    SETTING : Mopani District, South Africa. OBJECTIVE : To explore remote, molecular detection of Mycobacterium tuberculosis from sputum transported using PrimeStorew Molecular Transport Medium (PSMTM) compared to settings ...
  • Multicentre study to establish interpretive criteria for clofazimine drug susceptibility testing 
    Ismail, Nazir Ahmed; Said, H.M.; Rodrigues, C.; Omar, Shaheed Vally; Ajbani, K.; Sukhadiad, N.; Kohl, T.A.; Niemann, S.; Kranzer, K.; Diels, M.; Rigouts, L.; Rusch-Gerdes, S.; Siddiqi, S. (International Union Against Tuberculosis and Lung Disease, 2019-05)
    To conduct a multicentre study to establish the critical concentration (CC) for clofazimine (CFZ) for drug susceptibility testing (DST) of Mycobacterium tuberculosis on the MGIT™960™ system using the distribution of minimum ...
  • Next-generation ion torrent sequencing of drug resistance mutations in Mycobacterium tuberculosis strains 
    Daum, Luke T.; Rodriguez, John D.; Worthy, Sue A.; Ismail, Nazir Ahmed; Omar, Shaheed Vally; Dreyer, Andries W.; Fourie, P.B. (Petrus Bernardus); Hoosen, Anwar Ahmed; Chambers, James P.; Fischer, Gerald W. (American Society for Microbiology, 2012-12)
    A novel protocol for full-length Mycobacterium tuberculosis gene analysis of first- and second-line drug resistance was developed using the Ion Torrent Personal Genome Machine (PGM). Five genes—rpoB (rifampin), katG ...
  • Next-generation sequencing for identifying pyrazinamide resistance in Mycobacterium tuberculosis 
    Daum, Luke T.; Fourie, P.B. (Petrus Bernardus); Bhattacharyya, Sanjib; Ismail, Nazir Ahmed; Gradus, Steve; Maningi, N.E. (Nontuthuko Excellent); Omar, Shaheed Vally; Fischer, Gerald W. (Oxford University Press, 2014-03-15)
    No abstract available.
  • A novel molecular strategy for surveillance of multidrug resistant tuberculosis in high burden settings 
    Said, Halima M.; Kushner, Nicole; Omar, Shaheed Vally; Dreyer, Andries W.; Koornhof, Hendrik; Erasmus, Linda; Gardee, Yasmin; Rukasha, Ivy; Shashkina, Elena; Beylis, Natalie; Kaplan, Gilla; Fallows, Dorothy; Ismail, Nazir Ahmed (Public Library of Science, 2016-01-11)
    BACKGROUND In South Africa and other high prevalence countries, transmission is a significant contributor to rising rates of multidrug resistant tuberculosis (MDR-TB). Thus, there is a need to develop an early detection ...
  • Optimizing mycobacterial culture in smear-negative, human immunodeficiency virus-infected Tuberculosis cases 
    Ismail, Nazir Ahmed; Said, H.M. (Halima Mohammed); Pinini, Z.; Omar, Shaheed Vally; Beyers, N.; Naidoo, P. (Public Library of Science, 2015-11-06)
    INTRODUCTION Tuberculosis (TB) is a significant public health problem and the diagnosis in human immunodeficiency virus (HIV)—infected individuals is challenging. The use of mycobacterial culture remains an important ...
  • Performance evaluation of three commercial molecular assays for the detection of Mycobacterium tuberculosis from clinical specimens in a high TB-HIV-burden setting 
    Matabane, M.M.Z.; Ismail, Farzanah; Strydom, Kathy-Anne; Onwuegbuna, O.; Omar, Shaheed Vally; Ismail, Nabila (BioMed Central, 2015-11-09)
    BACKGROUND : A major challenge faced by countries with a high burden of tuberculosis (TB) is early detection especially in individuals with paucibacillary disease which is common in HIV endemic settings. Remarkable efforts ...
  • Performance of a novel algorithm using automated digital microscopy for diagnosing tuberculosis 
    Ismail, Nazir Ahmed; Omar, Shaheed Vally; Lewis, James J.; Dowdy, David W.; Dreyer, Andries W.; Van der Meulen, Hermina; Nconjana, George; Clark, David A.; Churchyard, Gavin J. (American Thoracic Society, 2015-06)
    RATIONALE : TBDx automated microscopy is a novel technology that processes digital microscopic images to identify acid-fast bacilli (AFB). Use of TBDx as part of a diagnostic algorithm could improve the diagnosis of ...
  • Population-based resistance of Mycobacterium tuberculosis isolates to pyrazinamide and fluoroquinolones : results from a multicountry surveillance project 
    Zignol, Matteo; Dean, Anna S.; Alikhanova, Natavan; Andres, Sonke; Cabibbe, Andrea Maurizio; Cirillo, Daniela Maria; Dadu, Andrei; Dreyer, Andries; Driesen, Michèle; Gilpin, Christopher; Hasan, Rumina; Hasan, Zahra; Hoffner, Sven; Husain, Ashaque; Hussain, Alamdar; Ismail, Nazir Ahmed; Kamal, Mostofa; Mansjo, Mikael; Mvusi, Lindiwe; Niemann, Stefan; Omar, Shaheed Vally; Qadeer, Ejaz; Rigouts, Leen; Ruesch-Gerdes, Sabine; Schito, Marco; Seyfaddinova, Mehriban; Skrahina, Alena; Tahseen, Sabira; Wells, William A.; Mukadi, Ya Diul; Kimerling, Michael; Floyd, Katherine; Weyer, Karin; Raviglione, Mario C. (Elsevier, 2016-10)
    BACKGROUND : Pyrazinamide and fluoroquinolones are essential antituberculosis drugs in new rifampicin-sparing regimens. However, little information about the extent of resistance to these drugs at the population level is ...
  • Pre-detection history of extensively drug-resistant tuberculosis in KwaZulu-Natal, South Africa 
    Brown, Tyler S.; Challagundla, Lavanya; Baugh, Evan H.; Omar, Shaheed Vally; Mustaev, Arkady; Auld, Sara C.; Shah, N. Sarita; Kreiswirth, Barry N.; Brust, James C.M.; Nelson, Kristin N.; Narechania, Apurva; Kurepina, Natalia; Mlisana, Koleka; Bonneau, Richard; Eldholm, Vegard; Ismail, Nazir Ahmed; Kolokotronis, Sergios-Orestis; Robinson, D. Ashley; Gandhi, Neel R.; Mathema, Barun (National Academy of Sciences, 2019-11)
    Antimicrobial-resistant (AMR) infections pose a major threat to global public health. Similar to other AMR pathogens, both historical and ongoing drug-resistant tuberculosis (TB) epidemics are characterized by transmission ...
  • Prevalence of drug-resistant tuberculosis and imputed burden in South Africa : a national and sub-national cross-sectional survey 
    Ismail, Nazir Ahmed; Mvusi, Lindiwe; Nanoo, Ananta; Dreyer, Andries; Omar, Shaheed Vally; Babatunde, Sanni; Molebatsi, Thabo; Van der Walt, Martie; Adelekan, Adeboye; Deyde, Varough; Ihekweazu, Chikwe; Madhi, S.A. (Elsevier, 2018-07)
    BACKGROUND : Globally, per-capita, South Africa reports a disproportionately high number of cases of multidrug-resistant (MDR) tuberculosis and extensively drug-resistant (XDR) tuberculosis. We sought to estimate the ...
  • Prevalence of ESBL and MBL antibiotic resistance genes in Klebsiella pneumoniae in Pretoria Academic Hospital 
    Ehlers, Marthie Magdaleen; Hoosen, Anwar Ahmed; Omar, Shaheed Vally; Maningi, Nontuthuko Excellent; Makgothlo, E.; Kock, Marleen M.; Creative Studios, Dept of Education Innovation, University of Pretoria (2008-12-09)
    Extended-spectrum-beta-lactamases (ESBL) have been recovered from medical centres in South Africa since the late 1980’s but little is known about the various types of ESBLs present and their prevalence. Metallo-beta-lactamase ...
  • Rapid antibiotic-resistance predictions from genome sequence data for Staphylococcus aureus and Mycobacterium tuberculosis 
    Bradley, Phelim; Gordon, N. Claire; Walker, Timothy M.; Dunn, Laura; Heys, Simon; Huang, Bill; Earle, Sarah; Pankhurst, Louise J.; Anson, Luke; De Cesare, Mariateresa; Piazza, Paolo; Votintseva, Antonina A.; Golubchik, Tanya; Wilson, Daniel J.; Wyllie, David H.; Diel, Ronald; Niemann, Stefan; Feuerriegel, Silke; Kohl, Thomas A.; Ismail, Nazir Ahmed; Omar, Shaheed Vally; Smith, E. Grace; Buck, David; McVean, Gil; Walker, A. Sarah; Peto, Tim E.A.; Crook, Derrick W.; Iqbal, Zamin (Nature Publishing Group, 2015-12-21)
    The rise of antibiotic-resistant bacteria has led to an urgent need for rapid detection of drug resistance in clinical samples, and improvements in global surveillance. Here we show how de Bruijn graph representation of ...
  • Social mixing and clinical features linked with transmission in a network of extensively drug-resistant tuberculosis cases in KwaZulu-Natal, South Africa 
    Nelson, Kristin N.; Jenness, Samuel M.; Mathema, Barun; Lopman, Benjamin A.; Auld, Sara C.; Shah, N. Sarita; Brust, James C.M.; Ismail, Nazir Ahmed; Omar, Shaheed Vally; Brown, Tyler S.; Allana, Salim; Campbell, Angie; Moodley, Pravi; Mlisana, Koleka; Gandhi, Neel R. (Oxford University Press, 2020-06)
    BACKGROUND: Tuberculosis (TB) is the leading infectious cause of death globally, and drug-resistant TB strains pose a serious threat to controlling the global TB epidemic. The clinical features, locations, and social factors ...
  • Spatial patterns of extensively drug-resistant tuberculosis transmission in KwaZulu-Natal, South Africa 
    Nelson, Kristin N.; Shah, N. Sarita; Mathema, Barun; Ismail, Nazir Ahmed; Brust, James C.M.; Brown, Tyler S.; Auld, Sara C.; Omar, Shaheed Vally; Morris, Natashia; Campbell, Angie; Allana, Salim; Moodley, Pravi; Mlisana, Koleka; Gandhi, Neel R. (Oxford University Press, 2018-12-15)
    BACKGROUND : Transmission is driving the global drug-resistant tuberculosis (TB) epidemic; nearly three-quarters of drug-resistant TB cases are attributable to transmission. Geographic patterns of disease incidence, combined ...
  • Systematic rifampicin resistance errors with Xpert® MTB/RIF Ultra : implications for regulation of genotypic assays 
    Omar, Shaheed Vally; Hillemann, D.; Pandey, S.; Merker, M.; Witt, A.K.; Nadarajan, D.; Barilar, I.; Bainomugisa, A.; Kelly, E.C.; Diel, R.; Vidanagama, D.S.; Samarasinghe, A.I.P.; Cader, M.R.; Goetsch, U.; Lavu, E.; Alabi, A.; Schon, T.; Coulter, C.; Niemann, S.; Maurer, F.P.; Ismail, Nazir Ahmed; Koser, C.U.; Ismail, F. (International Union Against Tuberculosis and Lung Disease, 2020-12)
    No abstract available.