dc.contributor.author |
De Vries, Hugo
|
|
dc.contributor.author |
Geervliet, Mirelle
|
|
dc.contributor.author |
Jansen, Christine A.
|
|
dc.contributor.author |
Rutten, Victor P.M.G.
|
|
dc.contributor.author |
Van Hees, Hubert
|
|
dc.contributor.author |
Groothuis, Natalie
|
|
dc.contributor.author |
Wells, Jerry M.
|
|
dc.contributor.author |
Savelkoul, Huub F.J.
|
|
dc.contributor.author |
Tijhaar, Edwin
|
|
dc.contributor.author |
Smidt, Hauke
|
|
dc.date.accessioned |
2020-12-04T07:56:49Z |
|
dc.date.available |
2020-12-04T07:56:49Z |
|
dc.date.issued |
2020-10 |
|
dc.description.abstract |
Piglets are susceptible to infections in early life and around weaning due to rapid
environmental and dietary changes. A compelling target to improve pig health in early life is
diet, as it constitutes a pivotal determinant of gut microbial colonization and maturation of the
host’s immune system. In the present study, we investigated how supplementation of yeast-derived
β-glucans affects the gut microbiota and immune function pre- and post-weaning, and how these
complex systems develop over time. From day two after birth until two weeks after weaning, piglets
received yeast-derived β-glucans or a control treatment orally and were subsequently vaccinated
against Salmonella Typhimurium. Faeces, digesta, blood, and tissue samples were collected to study
gut microbiota composition and immune function. Overall, yeast-derived β-glucans did not affect
the vaccination response, and only modest effects on faecal microbiota composition and immune
parameters were observed, primarily before weaning. This study demonstrates that the pre-weaning
period offers a ‘window of opportunity’ to alter the gut microbiota and immune system through diet.
However, the observed changes were modest, and any long-lasting effects of yeast-derived β-glucans
remain to be elucidated. |
en_ZA |
dc.description.department |
Veterinary Tropical Diseases |
en_ZA |
dc.description.librarian |
pm2020 |
en_ZA |
dc.description.sponsorship |
The Dutch Research Council (NWO) and Vereniging Diervoeders Nederland (VDN) |
en_ZA |
dc.description.uri |
http://www.mdpi.com/journal/microorganisms |
en_ZA |
dc.identifier.citation |
De Vries, H., Geervliet, M., Jansen, C.A,. et al. 2020, 'Impact of yeast-derived β-glucans on the porcine gut microbiota and immune system in early life', Microorganisms, vol. 8, no, 10, art. 1573. pp. 1-24. |
en_ZA |
dc.identifier.issn |
2076-2607 (online) |
|
dc.identifier.other |
10.3390/microorganisms8101573 |
|
dc.identifier.uri |
http://hdl.handle.net/2263/77270 |
|
dc.language.iso |
en |
en_ZA |
dc.publisher |
MDPI |
en_ZA |
dc.rights |
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
en_ZA |
dc.subject |
β-glucans |
en_ZA |
dc.subject |
Porcine |
en_ZA |
dc.subject |
Gastro-intestinal tract |
en_ZA |
dc.subject |
Gut microbiota |
en_ZA |
dc.subject |
Immune system |
en_ZA |
dc.subject |
Early life |
en_ZA |
dc.title |
Impact of yeast-derived β-glucans on the porcine gut microbiota and immune system in early life |
en_ZA |
dc.type |
Article |
en_ZA |