dc.contributor.author |
Keter, Frankline K.
|
|
dc.contributor.author |
Guzei, Ilia A.
|
|
dc.contributor.author |
Nell, Margo Judith
|
|
dc.contributor.author |
Van Zyl, Werner E.
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|
dc.contributor.author |
Darkwa, James
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|
dc.date.accessioned |
2014-05-22T09:26:12Z |
|
dc.date.issued |
2014-02 |
|
dc.description.abstract |
The reactions of potassium salts of the dithiocarbamates L {where L = pyrazolyldithiocarbamate (L1), 3,5-dimethylpyrazolyldithiocarbamate (L2), or indazolyldithiocarbamate (L3)} with the gold precursors [AuCl(PPh3)], [Au2Cl2(dppe)], [Au2Cl2(dppp)], or [Au2Cl2(dpph)] lead to the new gold(I) complexes [AuL(PPh3)] (1–3), [Au2L2(dppe)] (4–6), [(Au2L2)(dppp)] (7–9), and [Au2(L)2(dpph)] (10–12) {where dppe = 1,2-bis(diphenylphosphino)ethane, dppp = 1,3-bis(diphenylphosphino)propane, and dpph = 1,6-bis(diphenylphosphino)hexane}. These gold compounds were characterized by a combination of NMR and infrared spectroscopy, microanalysis, and mass spectrometry; and in selected cases by single-crystal X-ray crystallography. Compounds 4–6, which have dppe ligands, are unstable in solution for prolonged periods, with 4 readily transforming to the Au18 cluster [Au18S8(dppe)6]Cl2 (4a) in dichloromethane. Compounds 1–3 and 7–12 are all active against human cervical epithelioid carcinoma (HeLa) cells, but the most active compounds are 10 and 11, with IC50 values of 0.51 μM and 0.14 μM, respectively. Compounds 10 and 11 are more selective toward HeLa cells than they are toward normal cells, with selectivities of 25.0 and 70.5, respectively. Further tests, utilizing the 60-cell-line Developmental Therapeutics Program at the National Cancer Institute (U.S.A.), showed 10 and 11 to be active against nine other types of cancers. |
en_US |
dc.description.embargo |
2015-02-28 |
|
dc.description.librarian |
hb2014 |
en_US |
dc.description.sponsorship |
Harmony Gold under project AuTEK, run by Mintek (South Africa), and University of Johannesburg. |
en_US |
dc.description.uri |
http://pubs.acs.org/IC |
en_US |
dc.identifier.citation |
Keter, FK, Guzei, IA, Nell, MJ, Van Zyl, WE & Darkwa, J 2014, 'Phosphinogold(I) dithiocarbamate complexes : effect of the nature of phosphine ligand on anticancer properties', Inorganic Chemistry, vol. 53, no. 4, pp. 2058-2067. |
en_US |
dc.identifier.issn |
0020-1669 (print) |
|
dc.identifier.issn |
1520-510X (online) |
|
dc.identifier.other |
10.1021/ic4025926 |
|
dc.identifier.uri |
http://hdl.handle.net/2263/39856 |
|
dc.language.iso |
en |
en_US |
dc.publisher |
American Chemical Society |
en_US |
dc.rights |
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Inorganic Chemistry, © 2014 American Chemical Society after peer review and technical editing by the publisher. |
en_US |
dc.subject |
Phosphinogold(I) |
en_US |
dc.subject |
Dithiocarbamate complexes |
en_US |
dc.subject |
Nature of Phosphine ligand |
en_US |
dc.subject |
Anticancer properties |
en_US |
dc.title |
Phosphinogold(I) dithiocarbamate complexes : effect of the nature of phosphine ligand on anticancer properties |
en_US |
dc.type |
Postprint Article |
en_US |