Serum lactate in canine babesiosis

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dc.contributor.advisor Lobetti, R.G. (Remo Giuseppe) en
dc.contributor.postgraduate Nel, Mirinda en
dc.date.accessioned 2013-09-06T14:02:46Z
dc.date.available 2005-03-03 en
dc.date.available 2013-09-06T14:02:46Z
dc.date.created 2005-02-17 en
dc.date.issued 2006-03-03 en
dc.date.submitted 2005-03-03 en
dc.description Dissertation (MMed Vet (Med))--University of Pretoria, 2004. en
dc.description.abstract Canine babesiosis typically causes a haemolytic anemia and results in hypoxia and sepsis, which can eventually result in multiple organ dysfunction. Human patients with severe injury or disease such as shock, sepsis and malaria often have persistent hyperlactataemia, and there is a correlation between blood lactate and survival rate. There are various similarities between human malaria and canine babesiosis, eg. anaemia, renal failure, cerebral forms, coagulopathy, hepatopathy, pulmonary oedema, and shock. In severe malaria, lactate levels in blood rise in direct proportion to the severity of the disease. Venous lactate concentrations measured at 4 hours after admission appears to be the best prognostic indicator in severe malaria. In dogs blood lactate has been shown to be of prognostic value in patients with gastric dilatationvolvulus and in dogs admitted to intensive care units. Blood lactate has also been shown to be of prognostic value in equine colic. Blood lactate was determined in ninety dogs with naturally occurring canine babesiosis. Forty-five dogs (50%) presented with hyperlactataemia (blood lactate > 2.5mmol/L) and 20 (22.2%) with hypoglycaemia (blood glucose < 3.3 mmol/L). Measurements significantly associated with mortality were hypoglycaemia on admission, blood lactate > 5mmol/L on admission, blood lactate > 2.5 mmol/L at 8, 16 and 24 hours after admission, and increase or < 50% decrease in blood lactate within 8 and 16 hours after admission. Blood lactate persistently > 4.4 mmol/L indicated a very poor prognosis. The study concluded that serial blood lactate measurements are useful in predicting survival in dogs with severe and complicated canine babesiosis. en
dc.description.availability unrestricted en
dc.description.department Companion Animal Clinical Studies en
dc.identifier.citation Nel, M 2005, Serum lactate in canine babesiosis, MMed dissertation, University of Pretoria, Pretoria, viewed yymmdd < http://hdl.handle.net/2263/22944 > en
dc.identifier.upetdurl http://upetd.up.ac.za/thesis/available/etd-03032005-121402/ en
dc.identifier.uri http://hdl.handle.net/2263/22944
dc.language.iso en
dc.publisher University of Pretoria en_ZA
dc.rights © 2005, University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. en
dc.subject No keywords available en
dc.subject UCTD en_US
dc.title Serum lactate in canine babesiosis en
dc.type Dissertation en


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