dc.contributor.author |
Suleiman, M.M. (Mohammed Musa)
|
|
dc.contributor.author |
Duncan, N.M. (Neil)
|
|
dc.contributor.author |
Eloff, Jacobus Nicolaas
|
|
dc.contributor.author |
Naidoo, Vinny
|
|
dc.date.accessioned |
2013-02-19T10:19:36Z |
|
dc.date.available |
2013-02-19T10:19:36Z |
|
dc.date.issued |
2012-10-31 |
|
dc.description.abstract |
BACKGROUND: The poultry industry due to intensive methods of farming is burdened with losses from numerous
infectious agents, of which one is the fungus Aspergillus fumigatus. In a preliminary study, the extracts of Loxostylis
alata A. Spreng, ex Rchb. showed good activity in vitro against A. fumigatus with a minimum inhibitory
concentration of 0.07 mg/ml. For this study crude, a crude acetone extract of L. alata leaves was evaluated for its
acute toxicity in a healthy chicken model and for efficacy in an infectious model of aspergillosis (A. fumigatus).
RESULTS: At a dose of 300 mg/kg, the extract induced some toxicity characterised by decreased feed intake and
weight loss. Consequently, 100 and 200 mg/kg were used to ascertain efficacy in the infectious model. The plant
extract significantly reduced clinical disease in comparison to the control in a dose dependant manner. The extract
was as effective as the positive control ketoconazole dosed at 60 mg/kg.
CONCLUSIONS: The results indicate that a crude extract of L. alata leaves has potential as an antifungal agent to
protect poultry against avian aspergillosis. |
en |
dc.description.librarian |
am2013 |
en |
dc.description.librarian |
mn2013 |
|
dc.description.sponsorship |
The South African National Research Foundation
and the Research Committee of the Faculty of Veterinary Science, University
of Pretoria |
en |
dc.description.uri |
http://www.biomedcentral.com/1746-6148/8/210 |
en |
dc.identifier.citation |
Suleiman et al.: A controlled study to determine the efficacy of Loxostylis alata (Anacardiaceae) in the treatment of aspergillus in a chicken (Gallus domesticus) model in comparison to ketoconazole. BMC Veterinary Research 2012 8:210. |
en |
dc.identifier.issn |
1746-6148 |
|
dc.identifier.other |
10.1186/1746-6148-8-210 |
|
dc.identifier.other |
7005589445 |
|
dc.identifier.other |
8621439700 |
|
dc.identifier.other |
A-1508-2008 |
|
dc.identifier.uri |
http://hdl.handle.net/2263/21087 |
|
dc.language.iso |
en |
en |
dc.publisher |
BioMed Central |
en |
dc.rights |
© 2012 Suleiman et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative
Commons Attribution License |
en |
dc.subject |
Loxostylis alata |
en |
dc.subject |
Aspergillosis |
en |
dc.subject |
Broiler chickens |
en |
dc.subject.lcsh |
Alternative veterinary medicine |
en |
dc.subject.lcsh |
Poultry -- Infections |
en |
dc.title |
A controlled study to determine the efficacy of Loxostylis alata (Anacardiaceae) in the treatment of aspergillus in a chicken (Gallus domesticus) model in comparison to ketoconazole |
en |
dc.type |
Article |
en |