Verwoerd, Daniel WynandDe Villiers, Ethel-MicheleTustin, R.C.Bigalke, R.D.Cameron, Colin McKenzieGilchrist, Frances M.C.Morren, A.J.Verster, Anna J.M.Steyn, P.J.J.2016-07-062016-07-0620161980Verwoerd, DW, De Villiers, EM & Tustin, RC 1980, 'Etiology of Jaagsiekte - Experimental Transmission to Lambs by Means of Cultured-Cells and Cell Homogenates’, Onderstepoort Journal of Veterinary Research, vol. 47, no. 1, pp. 13-18.0330-2465http://hdl.handle.net/2263/53842The articles have been scanned in colour with a HP Scanjet 5590; 300dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.Studies on the transmission of jaagsiekte (ovine pulmonary adenomatosis) both by sub inoculation of cells of known sex and by cell homogenates into male and female lambs are reported. The results obtained indicate a thymocyte-dependent rejection of male cells in female recipients in contrast to the successful transplantation of male cells in male animals and female cells in both sexes. This suggests the presence of a surface antigen determined by the Y-chromosome in the tumour cells. A second mechanism of transmission, dependent on the transformation of the recipient's cells, was demonstrated by 2 cases of heterologous transplantation and confirmed by inoculation of cellular homogenatesen©1980 ARC - Ondersterpoort and Faculty of Veterinary Science, University of Pretoria (original). ©2016 University of Pretoria Department of Library Services (digital).Veterinary medicineVeterinary medicine -- South AfricaArticle