Jacyk, Witold KamilGrayson, WayneDinkel, Jurgen ErichRequena, Luis2007-08-292007-08-292007-08Jacyk, WK, Grayson, W, Dinkel, JE & Requena, L 2007, ‘Pagetoid reticulosis with CD30 positivity and cytotoxic/suppressor cells’, Journal of Cutaneous Pathology, vol. 34, no. 8, pp. 644–647 [http://www.blackwell-synergy.com/loi/cup]1600-056010.1111/j.1600-0560.2006.00698.xhttp://hdl.handle.net/2263/3369Pagetoid reticulosis (PR), also named Woringer-Kolopp disease, is a low-grade primary cutaneous T-cell lymphoma that usually presents as a solitary, slowly enlarging erythematous or hyperkeratotic plaque on the distal areas of the extremities. Histopathologically, it is characterized by a dense, band-like infiltrate of atypical lymphocytes with prominent epidermotropism within a hyperplastic epidermis, and immunophenotypic studies show in most cases, a CD4-positive T-helper phenotype for the neoplastic lymphocytes. We describe an African man with a more than 20-year history of an acral lesion of PR, which was histopathologically characterized by lymphocyte immunophenotype consisting of CD8- and CD30-positive cells. We discuss the differential diagnosis with other primary cutaneous lymphoproliferative disorders showing similar immunophenotype. This case shows that CD30-positive PR should be included as a rare variant within the spectrum of CD30-positive primary cutaneous lymphoproliferative disorders. As in other primary cutaneous CD30-positive lymphoproliferative processes, lesions of CD30-positive PR show an indolent course and a benign biological behavior. Histopathologically, it shows a prominent infiltrate of atypical lymphocytes within a hyperplastic epidermis. Immunophenotypic studies in lesions of PR have led to the recognition of different phenotypes for the large atypical epidermotropic lymphocytes. The CD4-positive T-helper phenotype appears the most common.809460 bytesapplication/pdfenBlackwell. The definitive version is available at www.blackwell-synergy.comPagetoid reticulosisLymphomasSkin -- Diseases -- South AfricaPostprint Article