Safi, Mohammad A.Garba, Salisu M.Waniewski, Jacek2012-12-132012-12-132012Safi, MA & Garba, SM 2012, 'Global stability analysis of SEIR model with Holling type II incidence function', Computational and Mathematical Methods in Medicine, vol. 2012, no. Article ID 826052, pp. 1-8.1748-670X (print)1748-9718 (online)10.1155/2012/826052http://hdl.handle.net/2263/20804A deterministicmodel for the transmission dynamics of a communicable disease is developed and rigorously analysed. Themodel, consisting of five mutually exclusive compartments representing the human dynamics, has a globally asymptotically stable diseasefree equilibrium (DFE) whenever a certain epidemiological threshold, known as the basic reproduction number (R0), is less than unity; in such a case the endemic equilibrium does not exist. On the other hand, when the reproduction number is greater than unity, it is shown, using nonlinear Lyapunov function of Goh-Volterra type, in conjunction with the LaSalle’s invariance principle, that the unique endemic equilibrium of the model is globally asymptotically stable under certain conditions. Furthermore, the disease is shown to be uniformly persistent whenever R0 > 1.en© 2012 M. A. Safi and S. M. Garba. This is an open access article distributed under the Creative Commons Attribution License.SEIR modelHolling type II incidence functionArticle