Diedericks, B.Kok, Anna-MariMandiwana, VusaniLall, Namrita2025-04-082025-04-082024-02Diedericks, B.; Kok, A.-M.; Mandiwana, V.; Lall, N. A Review of the Potential of Poly-(lactide -co-glycolide) Nanoparticles as a Delivery System for an Active Antimycobacterial Compound, 7-Methyljuglone. Pharmaceutics 2024, 16, 216. https://doi.org/10.3390/pharmaceutics16020216.1424-8247 (online)10.3390/pharmaceutics16020216http://hdl.handle.net/2263/101921DATA AVAILABILITY STATEMENT: Data are contained within the article.This article belongs to the special issue titled 'Current Applications in Plant-Based Drug Delivery Nano Systems'.7-Methyljuglone (7-MJ) is a pure compound isolated from the roots of Euclea natalensis A. DC., a shrub indigenous to South Africa. It exhibits significant promise as a potential treatment for the highly communicable disease tuberculosis (TB), owing to its effective antimycobacterial activity against Mycobacterium tuberculosis. Despite its potential therapeutic benefits, 7-MJ has demonstrated in vitro cytotoxicity against various cancerous and non-cancerous cell lines, raising concerns about its safety for consumption by TB patients. Therefore, this review focuses on exploring the potential of poly-(lactide-co-glycolic) acid (PLGA) nanoparticles as a delivery system, which has been shown to decrease in vitro cytotoxicity, and 7-MJ as an effective antimycobacterial compound.en© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an Open Access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).Tuberculosis (TB)AntimycobacterialCytotoxicity7-methyljuglonePoly-(lactide-co-glycolide) (PLGA)NanoparticleSDG-03: Good health and well-beingSDG-09: Industry, innovation and infrastructureArticle