Perez-de-Oliveira, Maria EduardaDe Lima Morais, Thayna MeloLopes, Marcio AjudarteDe Almeida, Oslei PaesVan Heerden, Willem Francois PetrusVargas, Pablo Agustin2021-08-312021-08-312021Pérez-de-Oliveira ME, Morais TML, Lopes MA, Almeida OP, van Heerden WFP, Vargas PA. Ossifying fibromyxoid tumor of the oral cavity: rare case report and long-term follow-up. Autopsy and Case Reports [Internet]. 2021;11: e2020216. https://doi.org/10.4322/acr.2020.216.2236-1960 (online)10.4322/acr.2020.216http://hdl.handle.net/2263/81561Ossifying fibromyxoid tumor (OFMT) is a rare mesenchymal soft tissue benign neoplasm with an uncertain line of differentiation, which arises most frequently in extremities. The head and neck region involvement is uncommon, with only ten intraoral cases published in the English-language literature. One additional case of OFMT is reported here, including a literature review of intraoral reported cases. A 45-year-old female patient presented a painless nodule involving the buccal mucosa of approximately two years duration, measuring nearly 1.3 cm in maximum diameter. The main histopathological features include ovoid to round cells embedded in a fibromyxoid matrix with a perpheral shell of lamellar bone. Immunohistochemically, the tumor showed immunoreactivity for vimentin and S100. No recurrence has been detected after 7 years of follow-up.en© 2020 The Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.Head and neck neoplasmsSoft tissue neoplasmsMouthOssifying fibromyxoid tumor (OFMT)Article