Du Toit, NicolaVan Coller, RiaanAnderson, David G.Carr, JonathanBardien, Soraya2020-03-102019-10Du Toit, N., van Coller, R., Anderson, D.G. et al. Frequency of the LRRK2 G2019S mutation in South African patients with Parkinson’s disease. Neurogenetics 20, 215–218 (2019). https://doi.org/10.1007/s10048-019-00588-z.1364-6745 (print)1364-6753 (online)10.1007/s10048-019-00588-zhttp://hdl.handle.net/2263/73692G2019S in LRRK2 is the most common mutation associated with Parkinson’s disease (PD). Highest frequencies are in North African Arabic (30–41%) and Ashkenazi Jewish (6–30%) populations, mostly due to founder effects. Here, we investigated the frequency of G2019S in 647 unrelated South African PD patients from different ancestral origins. It was found in only 1.2% (8/647) of patients. Notably, none of the 91 individuals of African ancestry had G2019S. It was present in 1.9% (3/154) and 1% (5/493) of early- and late-onset cases, respectively. The frequency of G2019S exhibits ethnic-specific differences and warrants further study in sub-Saharan African populations.en© Springer-Verlag GmbH Germany, part of Springer Nature 2019. The original publication is available at : https://link.springer.com/journal/10048.Parkinson’s disease (PD)LRRK2 geneG2019S mutationPhenotypeSouth African patientsHealth sciences articles SDG-03SDG-03: Good health and well-beingPostprint Article