Weyers, Carmen ZendaMakhoba, Musa AubreyBlumenthal, Ryan2022-09-012023-03Weyers, C.Z., Makhoba, M.A. & Blumenthal, R. Pulmonary Aspiration of Brain Matter in a Motor Vehicle Fatality: A Case Study. American Journal of Forensic Medicine and Pathology, vol. 44, no. 1, pp. e1-e3, 2023. doi: 10.1097/PAF.0000000000000784.1533-404X (online)1533-404X (online)10.1097/PAF.0000000000000784https://repository.up.ac.za/handle/2263/87015We present the case of an adult man who was involved in a motor vehicle accident as a driver. Histological examination of the lung tissue showed the presence of brain tissue within the lumens of the bronchi and bronchioles. Aspiration of brain matter is a rare phenomenon, with only 1 case described in the literature. The finding of brain tissue within the bronchi and terminal bronchioles supports the scenario of a period of agonal respiration with consequent cerebral aspiration. This article adds to the limited literature, distinguishing antemortem or agonal aspiration from postmortem passive movement.en© 2022 Wolters Kluwer Health, Inc. All rights reserved. This is a non-final version of an article published in final form in American Journal of Forensic Medicine and Pathology, vol. 44, no. 1, pp. e1-e3, 2023. doi : 10.1097/PAF.0000000000000784.AspirationBrain matterMotor vehicle fatalityForensic pathologyPostprint Article