De Vos, JayneQuinn, LauraRoos, ClaudinePieters, RialetGorst-Allman, PeterRohwer, Egmont RichardGiesy, John P.Bouwman, Henk2014-11-042014-11-042013-05Vos JD, Quinn L, Roos C, Pieters R, Gorst-Allman P, Rohwer ER, Giesy JP & Bouwman H 2013, 'Experience in South Africa of combining bioanalysis and instrumental analysis of PCDD/Fs', TrAC Trends in Analytical Chemistry, vol. 46, no. 189-197.0165-9936 (print)1873-3689 (online)10.1016/j.trac.2013.02.003http://hdl.handle.net/2263/42476We outline the experiences and the challenges of optimizing two-dimensional gas chromatography coupled with time-of-flight mass spectrometry (GCxGC-TOF-MS) in conjunction with the H4IIE-luc bioassay for analyzing polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) in the South African context. Investigating such alternative analytical methods can assist countries with developing economies to meet their obligations under the Stockholm Convention.en© 2013 Elsevier Ltd. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in TrAC Trends in Analytical Chemistry. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in TrAC Trends in Analytical Chemistry, vol. 46, pp. 189-197, 2013. doi : 10.1016/j.trac.2013.02.003.BioanalysisH4IIE-luc bioassayPersistent organic pollutant (POP)Polychlorinated dibenzo-p-dioxin (PCDD)Polychlorinated dibenzofuran (PCDF)SoilStockholm conventionTime-of-flight mass spectrometry (TOF-MS)Two-dimensional gas chromatography (GCxGC)South Africa (SA)Postprint Article