Fonseca, Thamyres CamposAgostini, MichellePaes, Jefferson ViapianaRoza, Ana Luiza Oliveira CorreaVan Heerden, Willem Francois PetrusRomanach, Mario JoseAbrahao, Aline Correa2025-06-092024-12Fonsêca, T.C., Agostini, M., Paes, J.V. et al. Solitary Fibrous Tumor of the Mandible. Head and Neck Pathology 18, 124 (2024). https://doi.org/10.1007/s12105-024-01731-5.1936-055X (print)1936-0568 (online)10.1007/s12105-024-01731-5http://hdl.handle.net/2263/102741A 41-year-old woman presented with a facial asymmetry in the mental region and a painful, well-circumscribed, tender mass in the right lower buccal vestibule, associated with extensive ill-defined bone rarefaction with subtle cortical bone resorption. Microscopically, a proliferation of bland spindle cells interspersed with collagen fibers and prominent staghorn-like blood vessels was observed. Immunohistochemical analysis revealed strong positivity for CD34, Bcl-2, CD99, and STAT-6, confirming the diagnosis of Solitary Fibrous Tumor (SFT). Conservative surgical enucleation was performed, and 4 years later, recurrence was observed with extensive bone involvement and moth-eaten margins resembling a malignant tumor. SFT is a distinctive spindle cell tumor of fibroblastic differentiation, characterized by prominent branching staghorn-like vessels and a specific NAB2::STAT6 gene fusion. We herein contribute with a central SFT of the mandible with recurrent behavior and radiographic appearance suggesting malignancy.en© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. The original publication is available at : https://link.springer.com/journal/12105.Solitary fibrous tumor (SFT)OralRecurrentMandiblePostprint Article