Geel, Jennifer AnnEyal, Katherine ClaireHendricks, Marc GeraldMyezo, Khumo HopeStones, David KennethOmar, Fareed E.Goga, YasminVan Zyl, AnelVan Emmenes, BarryVaithilingum, ManickavallieIrusen, ShaeganBandini, Rossella MarinaWedi, OlokoRowe, BianceBallot, Daynia ElizabethMetzger, Monika L.2022-03-242022-03-242021Jennifer Ann Geel , Katherine Claire Eyal , Marc Gerald Hendricks , Khumo Hope Myezo , David Kenneth Stones , Fareed Omar , Yasmin Goga , Anel van Zyl , Barry van Emmenes , Manickavallie Vaithilingum , Shaegan Irusen , Rossella Marina Bandini , Oloko Wedi , Biance Rowe , Daynia Elizabeth Ballot , Monika L. Metzger & For the South African Children’s Cancer Study Group (2021): Prognostic factors affecting survival in children and adolescents with HIV and Hodgkin lymphoma in South Africa, Leukemia & Lymphoma, 62(12): 2854-2863, DOI: 10.1080/10428194.2020.1852472.1042-8194 (print)1029-2403 (online)10.1080/10428194.2020.1852472http://hdl.handle.net/2263/84626South African children with Hodgkin lymphoma (HL) and human immunodeficiency virus (HIV) have low 5-year overall survival (OS) rates. In this retrospective multicenter study, 271 South African pediatric patients with HL were studied to determine OS and prognostic factors in those with HIV and HL. Univariate risk factor analysis was performed to analyze prognostic factors. The 29 HIV-infected patients were younger (p = .021), more likely to present with wasting (0.0573), stunting (0.0332), and Stage IV disease (p = .000) than HIV-uninfected patients. The 5- and 10-year OS of HIV-infected patients of 49% and 45% versus 84% and 79%, respectively for HIV-uninfected patients (p = .0001) appeared to be associated with hypoalbuminemia (<20 g/dL) and CD4 percentage of <15%. Causes of death in the HIV-infected group included disease progression (6/14), infection (4/14), unknown (3/14), and second malignancy (1/14). HIV-infected pediatric patients with HL experience increased mortality due to post-therapy opportunistic and nosocomial infections.en© 2020 Informa UK Limited, trading as Taylor & Francis Group. This is an electronic version of an article published in Leukemia & Lymphoma, vol. 62, no. 12, pp. 2854-2863, 2021. doi : 10.1080/10428194.2020.1852472. Leukemia & Lymphoma is available online at : https://www.tandfonline.com/loi/ilal20.Hodgkin lymphomaChildrenAdolescentsHuman immunodeficiency virus (HIV)South Africa (SA)Prognostic factorsPostprint Article