Koetle, M.J.Motaung, Thabiso EricAmoo, S.O.2026-04-152026-04-152026Koetle, M.J., Motaung, T.E. and Amoo, S.O. (2026), Harnessing benzamides as plant stress inhibitors, growth promoters and in management of crop resilience—A review. Plant Biology https://doi.org/10.1111/plb.70150.1435-8603 (print)1438-8677 (online)10.1111/plb.70150http://hdl.handle.net/2263/109595Benzamides have emerged as potent stress inhibitors and growth promoters in plant biotechnology, particularly in the management of crop resilience. This review delves into the mechanisms of action, applications, and potential benefits of benzamides, especially focusing on their role as poly(ADP-ribose) polymerase (PARP) inhibitors. Benzamides modulate stress responses by inhibiting PARP activity, which is crucial for DNA repair and maintaining genomic stability. This inhibition prevents excessive poly(ADP-ribosyl)ation, conserving cellular energy and enhancing stress tolerance. Additionally, benzamides promote alternative DNA repair pathways, contributing to the timely repair of DNA lesions and reducing mutation accumulation. In plant stress management, classical PARP inhibitors like 3-methoxybenzamide (3-MBA) and 3-aminobenzamide (3-AB) have demonstrated efficacy in enhancing resistance to abiotic stresses, improving plant growth, and increasing transformation efficiency. This review also highlights the antimicrobial, herbicidal, and insecticidal properties of benzamides, which enhance plant defence mechanisms against various pests and diseases. In summary, benzamides offer multiple approaches to enhancing crop resilience and stress management, with significant implications for sustainable agriculture.en© 2025 The Author(s). Plant Biology published by John Wiley & Sons Ltd on behalf of German Society for Plant Sciences, Royal Botanical Society of the Netherlands. This is an open access article under the terms of the Creative Commons Attribution License.DNA repairDeoxyribonucleic acid (DNA)PARP inhibitorsPARylationPlant biotechnologyStress managementArticle