Cameron, Colin McKenzieFuls, W.J.P.Botha, Wilna F.Bigalke, R.D.Morren, A.J.Verster, Anna J.M.Verwoerd, Daniel WynandWalker, Jane B.Cameron, Colin McKenzieGilchrist, Frances M.C.Steyn, P.J.J.2016-07-062016-07-0620161979Cameron, CM, Fuls, WJP & Botha, WF 1979, 'Composition and evaluation of the efficacy of a Staphylococcus aureus vaccine.’, Onderstepoort Journal of Veterinary Research, vol. 46, no. 1, pp. 1-8.0330-2465http://hdl.handle.net/2263/53688This article has been scanned in colour with a HP Scanjet 5590; 300dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-Format.An alum-precipitated Staphylococcus aureus vaccine, composed of a formalin-inactivated whole culture of a strain which produces Smith surface antigen and combined with the whole culture of a highly toxigenic strain, was found to afford a good immunity to staphylococcal skin infection in rabbits. Three injections of the vaccine provided immunity which lasted for at least 6 months against a primarily pyogenic strain of S. aureus and for at least 3 months against a toxigenic strain. From experiments using vaccines prepared from cells or toxoid only, it was deduced that, although there is a measure of strain specific immunity, a good heterologous immunity can be established with a combined product provided that it contains adequate quantities of toxoid. The use of such a vaccine as a potential aid in the control of bovine staphylococcal mastitis is discussed.en©1979 ARC - Onderstepoort and Faculty of Veterinary Science, University of Pretoria (original). ©2016 University of Pretoria Department of Library Services (digital).Veterinary medicineVeterinary medicine -- South AfricaArticle