Murphy-Alford, Alexia J.Grossberg, Aaron J.Baracos, Vickie E.Barbar, MahaBauer, JudyBennett, Jonathan P.Fidarova, ElenaFuller, Clifton D.Loser, AnastassiaMoreno, Amy C.Patra, AnurimaPuttaswamy, DeepaRosenthal, David, I.Schoeman, JudyAnacak, Yavuz2026-02-132026-02-132026-01Murphy-Alford, A.J., Grossberg, A.J., Baracos, V.E. et al. 2026, 'Perspective : radiotherapy and body composition: unmet needs in low- and middle-income countries', Advances in Nutrition, vol. 17, no. 1, art. 100563, pp. 1-7, doi : 10.1016/j.advnut.2025.100563.2161-8313 (print)2156-5376 (online)10.1016/j.advnut.2025.100563http://hdl.handle.net/2263/108235Radiotherapy plays a vital role in cancer treatment, yet its effects on patients’ nutritional status can precipitate muscle loss, with significant implications for treatment tolerance and outcomes. Evidence from high-income countries increasingly links radiation-induced muscle loss to adverse clinical outcomes. In contrast, low- and middle-income countries face a stark evidence gap, despite the heightened vulnerability of cancer patients in these settings due to delayed diagnosis, limited access to care, and high rates of co-morbidities. This paper highlights the critical gaps in nutritional care for radiotherapy patients in low- and middle-income countries. STATEMENTS OF SIGNIFICANCE : Radiotherapy can affect body composition and consequently clinical outcomes, yet evidence from low- and middle-income countries remains limited despite heightened risks from delayed care and comorbidities. This perspective argues that generating context-specific body composition data and building evidence for integrating nutrition into radiotherapy services are critical steps to optimize treatment and improve survivorship in resource-limited settings.en© 2025 The Author(s). Published by Elsevier Inc. on behalf of American Society for Nutrition. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).Body compositionNutritionLow- and middle-income countries (LMICs)CancerRadiotherapyArticle