An, LijunMa, JunYang, XueyuanLiang, YueWang, HuimeiTuerhong, MuhetaerLall, NamritaAbudukeremu, MuniraZhang, YiLee, DonghoXu, JingWu, XiaohuiGuo, Yuanqiang2021-02-262020-05An, L., Ma, J., Yang, X. et al. 2020, 'Caseahomopene A, a ring-expanded homotriterpenoid from Casearia kurzii showing anti-inflammatory activities in vitro and in vivo', Bioorganic Chemistry, vol. 98, art. 103758, pp. 1-7.0045-206810.1016/j.bioorg.2020.103758http://hdl.handle.net/2263/78860Caseahomopene A (1), a rare natural product with a ring-expanded homotriterpenoid skeleton, was isolated from the leaves of Casearia kurzii. The structure including the absolute configuration was determined by spectroscopic data and X-ray crystallography analysis. Compound 1 showed anti-inflammatory effects in vitro and in vivo using LPS-stimulated cell and zebrafish model. As a potential anti-inflammatory agent, the anti-inflammatory mechanism of 1 was also investigated.en© 2020 Elsevier Inc. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Bioorganic Chemistry. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in Bioorganic Chemistry, vol. 98, art. 103758, pp. 1-7, 2020. doi : 10.1016/j.bioorg.2020.103758.HomotriterpenoidAnti-inflammationZebrafish modelMolecular dockingCasearia kurziiPostprint Article