Bosman, EdoleneEsterhuizen, Aletta DorotheaRodrigues, Frederico AntonioBecker, Piet J.Hoffmann, Willem Abraham2014-03-282014-03-282013-02Bosman, E, Esterhuizen, AD, Rodrigues, FA, Becker, PJ & Hoffmann, WA 2013, 'Prevalence of hyperinsulinaemia among normozoospermic donors at Medfem Clinic, South Africa', Andrologia, vol. 45, no. 1, pp. 18-25.0303-4569 (print)1439-0272 (online)10.1111/j.1439-0272.2012.01303.xhttp://hdl.handle.net/2263/37209The aim of this study was to investigate the prevalence of hyperinsulinaemia in a group of normozoospermic donors and the influence of insulin levels on in vitro fertilisation (IVF) outcome. Fasting insulin and 2 h post-eating insulin levels were determined for a group of thirty-four sperm donors. They were divided into three groups according to their insulin profiles. The association between insulin levels and embryo quality was determined in a clinical study for the different groups. The prevalence of raised insulin in the donor group was 44% with a 95% confidence interval of 27.2% and 62.1%. Donors with normal insulin levels produced more good quality blastocysts in the IVF programme than those with abnormal insulin levels. These differences were not statistically significant (P = 0.8638). Embryo quality in an IVF programme may be influenced by male insulin levels. The role of insulin in male fertility needs to be investigated.en© 2012 Blackwell Verlag GmbH.The definite version is available at : http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1439-0272Embryo qualityFasting insulinHyperinsulinaemiaTwo hour post-eating insulinFertility -- Endocrine aspectsPostprint Article