Top, ChouseinTsakou, KyriakiSioutas, GeorgiosJongejan, FransPapadopoulos, Elias2024-01-152024-01-152023-11Sioutas, G., Tsakou, K., Top, C. et al. 2023, 'First clinical case of tick-borne encephalitis (TBE) in a dog in Greece', Ticks and Tick-borne Diseases, vol. 14, art. 102226, pp. 1-4. https://DOI.org/10.1016/j.ttbdis.2023.102226.1877-959X10.1016/j.ttbdis.2023.102226http://hdl.handle.net/2263/93964Tick-borne encephalitis virus (TBEV) causes tick-borne encephalitis (TBE), affecting human health in Europe and Asia. Reports on canine clinical cases of TBE are rare, although dogs are used as sentinels for assessing human health risks. The first canine clinical TBE case in Greece is reported in this case report. The dog had a history of tick infestation and displayed neurological symptoms, particularly tetraparesis, neck hyperalgesia, and a sudden behavior change. Serum samples were obtained and examined in a commercial ELISA to detect anti-TBEV specific IgG and IgM antibodies. The dog tested seropositive for both IgG and IgM, and based on its history and compatible clinical signs, the diagnosis of TBE infection was reached. The prognosis was initially poor, and treatment included the administration of fluids, corticosteroids, and antibiotics, followed by physical therapy. After a 10-day hospitalization, the dog had a much better prognosis. This case highlights that TBEV does emerge in new locations, increasing human and animal infection risk. Veterinarians should include TBE in their differential diagnosis of canine patients with a history of tick infestations, progressive neurological symptoms, and abnormal behavior.en© 2023 The Authors. Published by Elsevier GmbH. This is an open access article under the CC BY-NC-ND license.CanineEuropeIxodes ricinusNeurological signsTick-borne disease (TBD)Dogs (Canis familiaris)Tick-borne encephalitis virus (TBEV)Tick-borne encephalitis (TBE)SDG-03: Good health and well-beingArticle