Binta, M.G.Mushi, E.Z.Rurangirwa, F.R.Verwoerd, Daniel Wynand2013-08-152013-08-1520131996Binta, MG, Mushi, EZ & Rurangirwa, FR 1996, 'Effect of cyclophosphamide on the acquisition of resistance to infestation by Rhipicephalus appendiculatus in rabbits’. Onderstepoort Journal of Veterinary Research, vol. 63, no. 1, pp. 7-10.0330-2465http://hdl.handle.net/2263/22026The articles have been scanned in colour with a HP Scanjet 5590; 600dpi. Adobe Acrobat X Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.Parenteral administration of cyclophosphamide in rabbits made resistant to infestation by the tick Rhipicephalus appendiculatus, resulted in abrogation of the resistance phenomenon. As a result, a high percentage (83%) of the larval ticks fed to repletion. This was in contrast to the control rabbits which were expressing the phenomenon of resistance to infestation by the ticks. In the latter, only 28% of the ticks fed to repletion. Cyclophosphamide administration in rabbits induced a leucopenia and depressed antibody response to the heterologous antigen, sheep red-blood cells.en© ARC-Onderstepoort (original). © University of Pretoria. Dept of Library Services (digital).Veterinary medicineCyclophosphamideEffectInfestationRabbitsResistanceRhipicephalus appendiculatusVeterinary medicine -- South AfricaRabbits -- DiseasesArticle