Du Plessis, J.L.Bigalke, R.D.2015-04-012015-04-0120141985Prozesky, L & du Plessis, JL 1985, 'The pathology of heartwater. I. A study of mice infected with the Welgevonden strain of Cowdria ruminantium’, Onderstepoort Journal of Veterinary Research, vol. 52, no. 2, pp. 71-79.0330-2465http://hdl.handle.net/2263/44228The articles have been scanned in colour with a HP Scanjet 5590; 600dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.Gross and microscopical lesions in mice intravenously infected with the Welgevonden strain of Cowdria ruminantium closely resembled the lesions described in cattle, sheep and goats. A high concentration of organisms was present in alveolar endothelial cells. Cytopathic changes in parasitized and non-parasitized endothelial cells and the morphology of the organisms are described and compared with the Ball₃ strain of C. ruminantium. Possible mechanisms in the development of the lung oedema are considered and the role of mice as animal model is discussed.en©ARC - Onderstepoort and Faculty of Veterinary Science, University of Pretoria (original). ©University of Pretoria. Dept. of Library Services (digital).Veterinary medicineVeterinary medicineArticle