Heath, Livio EdwardVan Rensburg, H.G. (Hester Gertruida)Boomker, Jacob Diederik Frederik2012-06-042012-06-0420122001Heath, LE, Van Rensburg, HG, Vosloo, W & Nel, LH 2001, 'The 3A non-structural-protein coding region of the southern African SAT type isolates differs from that of other foot-and-mouth disease viruses’. Onderstepoort Journal of Veterinary Research, vol. 68, no. 4, pp. 253-262.0030-2465http://hdl.handle.net/2263/19090The articles have been scanned in colour with a HP Scanjet 5590; 600dpi. Adobe Acrobat v.9 was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.The 3A non-structural protein of foot-and-mouth disease viruses is a relatively conserved protein comprising 153 amino acids. Recent studies have demonstrated correlation between mutations in the 3A non-structural-protein-coding region, including a 10-amino acid deletion, and attenuation of the viruses in cattle. Although the 3A coding region of several type A, O and C isolates has previously been described, nucleotide sequence data of the 3A coding region of the South African Types (SAT) 1, 2 and 3 viruses are limited. Therefore, the 3A non-structural-coding region of different SAT serotypes was determined, analysed and compared to that of European, South American and Asian isolates. The 3A regions of the SAT isolates investigated differed markedly from that of types A, O, C and Asia-1, but were similar within the group.© ARC-Onderstepoort and Faculty of Veterinary Science, University of Pretoria (original). © University of Pretoria. Dept of Library Services (digital).Veterinary medicineFoot-and-mouth disease virusPicornavirusSAT types3A non-structural proteinVeterinary medicine -- South AfricaFoot-and-mouth disease -- South AfricaCattle -- Virus diseases Article