Dzikiti, Tarisai BrightonStegmann, George F.Dzikiti, Loveness NyaradzoHellebrekers, Ludo J.2012-08-152012-08-152011-04Dziki, TB, Stegmann, GF, Dziki, LN & Hellebrekers, LJ 2011, 'Effects of fentanyl on isoflurane minimum alveolar concentration and cardiovascular function in mechanicallly ventilated goats', Veterinary Record, vol. 168, no. 16.0042-4900 (print)2042-7670 (online)10.1136/vr.d99927967665100N-8696-2014http://hdl.handle.net/2263/19597Effects of fentanyl on minimum alveolar concentration (MAC) of isoflurane and cardiovascular function in mechanically-ventilated goats were evaluated using six healthy goats (3 does and 3 wethers). Following induction of general anaesthesia with isoflurane, endotracheal intubation was performed and anaesthesia maintained with isoflurane. Baseline isoflurane MAC in response to clamping a claw with a Vulsellum forceps was determined. Immediately after baseline isoflurane MAC determination, the goats then received, on separate occasions, one of three fentanyl treatments intravenously: bolus of 0.005 mg/kg followed by constant rate infusion (CRI) of 0.005 mg/kg/hour (Treatment LFENT), bolus of 0.015 mg/kg followed by CRI of 0.015 mg/kg/hour (Treatment MFENT), bolus of 0.03 mg/kg followed by CRI of 0.03 mg/kg/hour (Treatment HFENT). Isoflurane MAC was re-determined during fentanyl CRI treatments. Cardiopulmonary parameters were monitored. Quality of recovery was scored. A four-week washout period was allowed between treatments. The observed baseline isoflurane MAC was 1.32 (1.29-1.36)%. Isoflurane MAC decreased to 0.98 (0.92-1.01)%, 0.75 (0.69-0.79)% and 0.58 (0.51- 0.65)% following LFENT, MFENT and HFENT respectively. Cardiovascular function was not adversely affected. Quality of recovery from general anaesthesia was good, although exaggerated tail-wagging was observed on some goats following MFENT and HFENT. Fentanyl reduces isoflurane MAC in a dosedependent manner with minimal adverse cardiovascular effects in healthy, mechanically-ventilated goats.enBMJ Publishing Group Ltd 2011.FentanylAlveolar concentrationIsofluranceCardiovascular functionGoatsVeterinary medicine -- ResearchGoats -- DiseasesPostprint Article