Olawode, Emmanuel O.Tandlich, RomanPrinsloo, EarlIsaacs, MichelleHoppe, HeinrichSeldon, RonnettWarner, Digby F.Steenkamp, VanessaKaye, Perry T.2019-08-282019-07Olawode, E.O., Tandlich, R., Prinsloo, E. et al. 2019, 'Synthesis and biological evaluation of 2-chloro-3-[(thiazol-2-yl)amino]-1,4-naphthoquinones', Bioorganic and Medicinal Chemistry Letters, vol. 29, no. 13, pp. 1572-1575.0960-894X (print)1464-3405 (online)10.1016/j.bmcl.2019.05.001http://hdl.handle.net/2263/71217A series of novel, substituted 2-chloro-3-[(thiazol-2-yl)amino]-1,4-naphthoquinones have been prepared and shown to exhibit promising concentration-dependent activity against human SH-SY5Y cells, Plasmodium falciparum, Mycobacterium tuberculosis and P. aeruginosa. Substituent effects on observed bioactivity have been explored; the para-fluorophenyl derivative 3d exhibited activity across the range of the bioassays employed, indicating the potential of the 2-chloro-3-[(4-arylthiazol-2-yl)amino]-1,4-naphthoquinone scaffold in the development of novel, broad spectrum therapeutics.en© 2019 Elsevier Ltd. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Bioorganic and Medicinal Chemistry Letters. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in Bioorganic and Medicinal Chemistry Letters, vol. 29, no. 13, pp. 1572-1575, 2019. doi : 10.1016/j.bmcl.2019.05.001.2-Chloro-3-[(thiazol-2-yl)amino]-1,4-naphthoquinonesAnti-malarialAnti-bacterialAnti-tuberculosisCytotoxicityHeLa cellsPostprint Article