Kaikabo, Adamu AhmadEloff, Jacobus Nicolaas2012-01-122012-01-122011-10Kaikabo, AA & Eloff, JN 2011, 'Antibacterial activity of two biflavonoids from Garcinia livingstonei leaves against Mycobacterium smegmatis'. Journal of Ethnopharmacology, vol. 138, no. 1, pp. 253-255.0378-8741 (print)1872-7573 (online)10.1016/j.jep.2011.08.0237005589445E-6204-2012http://hdl.handle.net/2263/17760Amentoflavone and 4′ monomethoxy amentoflavone were previously isolated from Garcinia livingstonei leaves. These compounds had good activities (MIC 6 and 8 μg/ml) against some nosocomial bacteria. In this study, the activity of these purified compounds were tested against fast-growing non-pathogenic Mycobacterium smegmatis. Amentoflavone was the most active compound, with an MIC of 0.60 ± 0.70 mg/ml. The MIC of 4′ monomethoxy amentoflavone and the positive control isoniazid against Mycobacterium smegmatis were similar 1.40 ± 1.56 and 1.30 ± 1.70 mg/ml respectively. Although, Mycobacterium smegmatis is a non-pathogenic fast growing mycobacterium the activities of these compounds may also be useful in combating infections by pathogenic Mycobacterium spp.en© 2011 Elsevier Ireland Ltd. All rights reserved.Amentoflavone4′ monomethoxy amentoflavoneAntimycobacterial activityTuberculosis (TB)Antibacterial agentsMateria medica, Vegetable -- South AfricaPostprint Article