Yadavalli, Venkata S. SarmaLabeodan, Moremi Morire OreOluwapoUdayabaskaran, SwaminathanMwanga, Y.A.2010-07-072010-07-072009Yadavalli, VSS, Labeodan, MMO, Udayabaskaran, S & Mwanga, Y 2009, 'A stochastic model of the dynamics of HIV under a combination therapeutic intervention', Orion: Operations Research in South Africa, vol. 25, no. 1, pp. 17-30. [http://www.orssa.org.za/]0529-191Xhttp://hdl.handle.net/2263/14407Drug resistance to single therapeutic treatment in HIV infected individuals has promoted research into combined treatments. In this paper we propose a stochastic model under combined therapeutic treatment by extending the model of HIV pathogenesis under treatment by anti-viral drugs given in [Perelson AS, Neumann AU, Markowits M, Leonard JM & Ho DD, 1996, HIV-1 dynamics in vivo virion clearance rate, infected cell life span, and viral generation time, Science New Series, 271, pp. 1582-1586]. Variance and co-variance structures of variables are obtainable via this approach in addition to the mean numbers of free HIV, infectious free HIV and non-infectious free HIV that were obtained by Perelson et al. Comparing simulated data for before and after treatment indicates the importance of combined treatment and its overall e ect(s).enOperations Research Society of SACombined therapyDrug resistanceInfectious free HIVStochastic modelArticle