Fabunmi, Oyesanmi A.Adeniyi, Mayowa J.Lenting, AndreaMasilela, ThulaniJanse van Rensburg, Dina Christina2026-04-102026-04-102026-02Fabunmi, O.A., Adeniyi, M.J., Lenting, A., Masilela, T., & Janse van Rensburg, D.C. (. (2026). Orthostatic blood pressure changes among adults in Ekiti state, Nigeria: Impact of socio-demographic, anthropometric, and biophysical factors. Physiological Reports, 14, e70792: 1-12. https://doi.org/10.14814/phy2.70792.2051-817X (online)10.14814/phy2.70792http://hdl.handle.net/2263/109510DATA AVAILABILITY STATEMENT : Data generated or analyzed during this study are available from the corresponding author upon reasonable request. SUPPLEMENTARY MATERIAL TABLE S2. (A) Association between orthostatic MAP and occupation. (B) Association between orthostatic MAP and educational status. TABLE S4. (A) Association between orthostatic MAP and occupation. (B) Association between orthostatic MAP and educational status.Orthostatic intolerance is the inability to maintain upright posture, a key manifestation of autonomic dysfunction that can lead to orthostatic hypotension (OH). We aimed to investigate orthostatic blood pressure (BP) changes among cohorts living in Ekiti State and to explore plausible underlying factors. We encompassed 140 participants (28% male; 72% female; age range: 18–70 years) in our preliminary study. Socio-demographic and anthropometric indices were collected using appropriate tools. Orthostatic responses were assessed at baseline, standing, and sitting following standardized protocols. Systolic (BP) decreased significantly by 4% after 1-min standing (130 ± 22 mmHg) compared to baseline (137 ± 20 mmHg). Diastolic (BP) increased significantly by 6.1% at 3 min (87 ± 13 mmHg) and 4.8% at 5 min (86 ± 12 mmHg) compared to baseline (82 ± 11 mmHg) (p < 0.001). Occupation (traders) and education level (secondary) are positively associated with mean arterial pressure (MAP) at 1- and 3-min standing times (p < 0.05). Orthostatic MAP at 1, 3, and 5 min correlated negatively with height but positively with body mass index (BMI), hip, and waist circumference (p < 0.05). These preliminary findings suggest a potential role for body composition and lifestyle in regulating autonomic cardiovascular function in response to postural changes.en© 2026 The Author(s). Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society. This is an open access article under the terms of the Creative Commons Attribution License.AdultsOrthostasisNigeriaHemodynamic changesEkiti stateArticle