Brunner, HermineTzaribachev, NikolayLouw, IngridPenades, Inmaculada CalvoAvila-Zapata, FranciscoHorneff, GerdFoeldvari, Ivan J.Kingsbury, Daniel J.Gastanaga, Maria Eliana PazWouters, CarineBreedt, JohannesWong, RobertAskelson, MargaritaZhuo, JoeMartini, Alberto J.Lovell, DanielRuperto, Nicolino2024-03-052024-03-052023-11Brunner, H.I., Tzaribachev, N., Louw, I., et al. 2023, 'Long-term maintenance of clinical responses by individual patients with polyarticular-course juvenile idiopathic arthritis treated with abatacept', Arthritis Care and Research, vol. 75, no. 11, pp. 2259-2266, doi : 10.1002/acr.25156.2151-464X (print)2151-4658 (online)10.1002/acr.25156http://hdl.handle.net/2263/95084SUPPLEMENTARY MATERIAL 1 : Disclosure form.SUPPLEMENTARY MATERIAL 2 : SUPPLEMENTARY FIGURE 1. Heat maps of individual patients in each cohort treated with SC abatacept who met combined response criteria at month 4: A) LDA+pain-min and B) LDA+CHAQ-DI0. SUPPLEMENTARY FIGURE 2. Patients treated with IV abatacept meeting composite endpoints LDA+pain-min and ACR50+pain-min. SUPPLEMENTARY FIGURE 3. Patients treated with SC abatacept meeting composite endpoints: A) LDA+pain-min, B) LDA+CHAQ-DI0, or C) ACR50+pain-min.SUPPLEMENTARY MATERIAL 3 : SUPPLEMENTARY TABLE 1. Baseline demographics and disease characteristics in the IV abatacept trial (1).OBJECTIVE : To investigate the frequency and trajectories of individual patients with polyarticular-course juvenile idiopathic arthritis (JIA) achieving novel composite end points on abatacept. METHODS : Data from a clinical trial of subcutaneous abatacept (NCT01844518) and a post hoc analysis of intravenous abatacept (NCT00095173) in patients with polyarticular-course JIA were included. Three end points were defined and evaluated: combined occurrence of low disease activity (LDA) measured by the Juvenile Arthritis Disease Activity Score; 50% improvement in American College of Rheumatology criteria for JIA (ACR50); and patient-reported outcomes. Patient-reported outcomes included visual analog scale score of minimal pain (pain-min) and Childhood Health Assessment Questionnaire disability index score of 0 (C-HAQ DI0). In this post hoc analysis, maintenance of month 13 and 21 end points (LDA+pain-min, LDA+C-HAQ DI0, and ACR50+pain-min) in those who achieved them at month 4 was determined. RESULTS : Composite end points (LDA+pain-min, LDA+C-HAQ DI0, and ACR50+pain-min) were achieved at month 4 (44.7%, 19.6%, and 58.9% of the 219 patients treated with subcutaneous abatacept, respectively). Of those who achieved LDA+pain-min at month 4, 84.7% (83 of 98) and 65.3% (64 of 98) maintained LDA+pain-min at months 13 and 21, respectively. The proportions of patients meeting LDA+pain-min outcomes increased from 44.7% (98 of 219) at month 4 to 54.8% (120 of 219) at month 21. The frequency of patients who met an LDA+C-HAQ DI score of 0 increased from 19.6% (43 of 219) at month 4 to 28.8% (63 of 219) at month 21. CONCLUSION : Among individual patients with polyarticular-course JIA treated with abatacept who achieved 1 of the combined clinical and patient-reported outcomes composite end points, many maintained them over 21 months of abatacept treatment.en© 2023 The Authors. Arthritis Care & Research published by Wiley Periodicals LLC on behalf of American College of Rheumatology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License.Juvenile idiopathic arthritis (JIA)Frequency patternTrajectoriesPolyarticular-courseAbataceptSDG-03: Good health and well-beingArticle