Tsemeugne, JosephBah, Yetiny A.Dzoyem, Jean PaulDzoyem, Jean PaulNdefongang, Jerome N.Famuyide, Ibukun MichaelMcGaw, Lyndy JoyNangmo, Pamela K.Ouahouo, Blandine M.W.Mkounga, PierreEdwards, GilesSimon, Peter F.W.Tsopmo, ApollinaireSopbue, Emmanuel F.Nkengfack, Augustin E.2023-04-242023-04-242022Tsemeugnehm, J., Bah, Y.A., Dzoyem, J.P. et al. 2022, 'Synthesis and anticancer activity evaluation of some new 1,2,3,5-tetrazine derivatives attached to benzothiazole moiety', Arkivoc, vol. 2022, no. ix, pp. 1-17, doi : 10.24820/ark.5550190.p011.866.1551-7012 (print)1551-7004 (online)10.24820/ark.5550190.p011.866http://hdl.handle.net/2263/90431A series of novel tetrazine derivatives, containing benzothiazole framework, were prepared during the coupling reactions of some diazotized 2-aminobenzo[d]thiazole derivatives with p-acetaminophen. Their structures were elucidated based on NMR and MS spectrometry. The anticancer activity and the safety of the synthesized compounds along with the entire precursors were assessed against three human cancer cell lines and a normal cell line. All the synthesized compounds showed selective cytotoxic activity against the cancer cell lines used in comparison to the normal Vero cell line. Their IC50 values varied from 2.02 to 171.67 μM.en© Author(s). This paper is an open access article distributed under the terms of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).TetrazineBenzothiazoleAcetaminophenAzo dyesAnticancer activityArticle